Physiological and Appetitive Effects of CBD Supplementation

Loughborough University30 enrolled

Overview

CBD may affect metabolic control and energy intake. However, there is currently little data regarding these specific outcomes in humans. Therefore, this study will investigate whether four weeks of supplementation with 60 mg/day CBD affects energy intake at a single meal, and or fasting blood-based markers of appetite regulation and metabolic health. Healthy, adult volunteers will be assigned to placebo or CBD supplementation, in a randomized controlled trial, comparing changes in outcomes across the supplementation period between groups.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Enrollment

Conditions

Appetitive Behavior Adverse Effect Metabolic Health

Interventions

Cannabidiol (CBD) supplementationDIETARY_SUPPLEMENT

Daily supplementation with 1 ml hemp oil containing 60 mg CBD, applied orally

Placebo supplementationDIETARY_SUPPLEMENT

Daily supplementation with 1 ml hemp oil containing 0 mg CBD, applied orally

Eligibility

Sex: ALLMin age: 18 YearsMax age: 50 YearsHealthy volunteers:

Medical Language ↔ Plain English

Exclusion Criteria: * No history of any substance abuse * Have used tobacco regularly (\>2x in a week) within the past 6 months * Are suffering from any condition that may affect study outcomes * Currently use any prescription or over-the-counter medications (except for hormonal contraception and simple painkillers) * Have given a standard blood donation within 30 days of screening * Are currently pregnant or lactating * Are allergic/intolerant to any ingredients in food items we provide during the study (relevant allergens: oats, milk) Inclusion Criteria: * Males and females, aged 18-50, who do not meet the exclusion criteria

Locations (1)

Loughborough University

Loughborough, Leicestershire, United Kingdom

RECRUITING