Empagliflozin and Dapagliflozin in Patients Hospitalized for Acute Decompensated Heart Failure

Inclusion Criteria: * Patients 18 years of age with the capacity to provide written informed consent * Currently hospitalized for a primary diagnosis of acute/decompensated HF (HFrEF, HFmrEF,HFpEF), including symptoms and signs of fluid overload regardless of ejection fraction or diabetes status * In patients with HFpEF the diagnosis has to be confirmed according to the current HFpEF definition (by non-invasive testing: evidence of structural or functional changes in the heart as evidenced on echocardiography or by invasive testing as LVEDP assessment or right heart catheterisation). * Randomized no earlier than 24 hours and up to 10 days after initial presentation while still hospitalized * Stable as defined by: systolic blood pressure (SBP\>100 mmHg for the preceding 6 hours) * No intensification of IV diuretics within the last 6 hours, * No use of IV vasodilators within the last 6 hours, * No use of IV inotropes or levosimendan within the last 24 hours prior to randomization * Elevated NT-proBNP \>600 pg/mL during the current hospitalization in patients with HFrEF and \>300 pg/mL in patients with HFmrEF or HFpEF (or above 900 pg/ml if atrial fibrillation is present at admission independently from EF). * eGFR \>20 ml/min/1,73m2 Exclusion Criteria: * History of ketoacidosis * Type 1 diabetes * SGLT-2 Inhibitor at baseline or known allergy to SGLT-2 Inhibitors * Current active cancer with less than 2 years of life expectancy * Pulmonary embolism, cerebrovascular accident as the primary trigger for the current hospitalization * Cardiomyopathy based on infiltrative diseases (e.g. amyloidosis), accumulation diseases (e.g. haemochromatosis, Fabry disease), muscular dystrophies, cardiomyopathy with reversible causes (e.g. stress cardiomyopathy), hypertrophic obstructive cardiomyopathy or known pericardial constriction * Any severe (obstructive or regurgitant) valvular heart disease, expected to lead to surgery during the trial period * Women of child-bearing potential, defined as all women physiologically capable of becoming pregnant * Blood pH\<7.32 * \>1 episode of severe hypoglycaemia within the last 6 months under treatment with insulin or sulfonylurea * Acute symptomatic urinary tract infection or genital infection