The goal of this clinical trial is to examine the regional protein turnover in tendon tissue from patients with chronic patellar tendinopathy and comparing this to healthy controls. Further we will examine the effect of resistance training on protein turnover in healthy individuals.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Enrollment
36
Only the control group: 3 exercise bouts within the study period. Comparison between exercised and non-exercised leg.
Comparison of primary and secondary outcomes.
Institute of Sports Medicine Copenhagen
Copenhagen, Capital Region, Denmark
Protein turnover in tendon tissue from patients with chronic tendinopathy compared to healthy controls
Fractional synthesis rate (FSR) measured in % pr. day in the trypsin-soluble and trypsin-insoluble fraction
Time frame: 8 days
Tracer incorporation in isolated fractions of the tendon
15N hydroxyproline enrichment measured in Mole percent Excess in the trypsin-soluble and trypsin-insoluble fraction
Time frame: 8 days
Tracer incorporation in isolated fractions of the tendon
15N proline enrichment measured in Mole percent Excess in the trypsin-soluble and trypsin-insoluble fraction
Time frame: 8 days
Anterior-posterior dimensions of patella tendon
Measured in millimeter
Time frame: 8 days
Doppler flow in patella tendon
Classified in grading system from 0-3.
Time frame: 8 days
Subjective pain in patella tendon
Questionnaire
Time frame: 8 days
Subjective measure of physical activity and function
Questionnaire
Time frame: 1 day
Single-leg decline squat test
Subjective pain on a scale from 0-10
Time frame: 1 day
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One leg knee extension strength test
Only control-group.
Time frame: 8 days
Leg press strength test
Only control-group.
Time frame: 8 days