Ringer Lactate Preloading on Induction Dose Requirement of Propofol

National Medical College Birgunj60 enrolled

Overview

* To compare the effect (heart rate and mean arterial pressure) of Ringer Lactate preloading and without preloading on induction dose requirement of Propofol. * The Propofol requirement for induction dose with respect to loss of eyelash reflex in Ringer Lactate preloaded versus control group.

1. From the operation list, patients that meet the Inclusion criteria will be selected. (n=60) 2. Patients will be allocated into two participant groups. Group I and Group II respectively using Simple random sampling technique by Ballot method. Ballot method is to keep the list of patients that meet the inclusion criteria in two ballot box mentioning name and groups and do the lottery based selection for both groups and Patient code will be given. 3. Group I (n = 30) Preloading with Ringer Lactate 30 ml/kg over 30 mins prior to surgery will be done and Propofol dose (2mg / kg ) requirement for induction of anaesthesia will be noted. Group II (n = 30) No Preloading will be done and Propofol dose (2mg / kg) requirement for induction of anaesthesia will be noted. 4. Then, investigators will visualize for loss of eyelash reflex in both groups. 5. The hemodynamic response (heart rate, systolic blood pressure, diastolic blood pressure and mean arterial pressure) to intubation between the two participant groups will be noted. The total Propofol requirement for induction in Ringer Lactate preloaded versus control group will be recorded. 6. Drug administration and parameters recording will be done by the anaesthesiologist / under supervision

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

OTHER

Masking

TRIPLE

Enrollment

Conditions

Anesthesia Ringer's Lactate

Interventions

Ringer Lactate prior to surgery and PropofolDRUG

Ringer Lactate prior to surgery and Propofol dose requirement for induction of anaesthesia will be noted

Eligibility

Sex: ALLMin age: 18 YearsMax age: 45 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. Patients scheduled for elective surgeries 2. American Society of Anaesthesiologists (ASA) class I patients 3. Age between 18-45 years 4. Any surgery under general anaesthesia requiring endotracheal intubation 5. Body mass index (BMI) -18.5 - 24.9 6. Those providing written consent Exclusion Criteria: 1. Emergency surgery 2. Patients with multiple injuries, pregnancy 3. Airway Mallampati grade II, III and IV 4. Allergy to Ringer Lactate and Propofol.

Locations (1)

National Medical College Teaching Hospital

Birgunj, Madhesh, Nepal

RECRUITING

Outcomes

Primary Outcomes

Propofol dose Required (mg)

Propofol dose (mg) with aspect to weight (kg)

Time frame: Standard dosing in Operation

Total Propofol dose given (mg)

Propofol dose (mg)

Time frame: Visualization of loss of eyelash reflex

Loss of eyelash reflex (seconds)

Visualization of loss of eyelash reflex (seconds)

Time frame: Propofol given till loss of eyelash reflex

Secondary Outcomes

Units of Measure (e.g., weight and height)

Weight in kilograms, height in meters ( weight and height will be combined to report BMI in kg/m²).

Time frame: Preanaesthetic checkup, Day 1

Heart rate (beats / minute): After IV Propofol

Heart rate (beats / minute) will be measured with pulse oxymeter

Time frame: Immediately After IV Propofol

Heart rate (beats / minute): Baseline before IV fluid infusion

Heart rate (beats / minute) will be measured with pulse oxymeter

Time frame: Base line Before IV fluid infusion

Heart rate (beats / minute): At intubation (0 minute)

Heart rate (beats / minute) will be measured with pulse oxymeter

Time frame: At intubation (0 minute)

Heart rate (beats / minute): Post intubation (1 minute)

Heart rate (beats / minute) will be measured with pulse oxymeter

Central Contacts

Dr Arushi Jaiswal

CONTACT

+9779841675096 arushij.dr16@gmail.com

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.

Time frame: Post intubation (1 minute)

Heart rate (beats / minute): Post intubation (3 minute)

Heart rate (beats / minute) will be measured with pulse oxymeter

Time frame: Post intubation (3 minute)

Heart rate (beats / minute): Post intubation (5 minute)

Heart rate (beats / minute) will be measured with pulse oxymeter

Time frame: Post intubation (5 minute)

Heart rate (beats / minute): Post intubation (10 minute)

Heart rate (beats / minute) will be measured with pulse oxymeter

Time frame: Post intubation (10 minute)

Systolic blood pressure (mm Hg): Baseline before IV fluid infusion

Systolic blood pressure (mm Hg) will be recorded on vital monitor

Time frame: Baseline before IV fluid infusion

Systolic blood pressure (mm Hg): After IV Propofol

Systolic blood pressure (mm Hg) will be recorded on vital monitor

Time frame: Immediately After IV Propofol

Systolic blood pressure (mm Hg): At intubation (0 minute)

Systolic blood pressure (mm Hg) will be recorded on vital monitor

Time frame: At intubation (0 minute)

Systolic blood pressure (mm Hg): Post intubation (1 minute)

Systolic blood pressure (mm Hg) will be recorded on vital monitor

Time frame: Post intubation (1 minute)

Systolic blood pressure (mm Hg): Post intubation (3 minute)

Systolic blood pressure (mm Hg) will be recorded on vital monitor

Time frame: Post intubation (3 minute)

Systolic blood pressure (mm Hg): Post intubation (5 minute)

Systolic blood pressure (mm Hg) will be recorded on vital monitor

Time frame: Post intubation (5 minute)

Systolic blood pressure (mm Hg): Post intubation (10 minute)

Systolic blood pressure (mm Hg) will be recorded on vital monitor

Time frame: Post intubation (10 minute)

Diastolic blood pressure (mm Hg): Baseline before IV fluid infusion