This study aims to find an easy urinary collection method for the assessment of urinary markers of micronutrient status.
Urinary collection in newborns and infants can be difficult. Our study aims to find an easy and cheap alternative to urinary collection bags and specialized pads that can be used to measure biomarkers of iodine and vitamin B12 status in urine and can be employed in large scale trials. Using correlation analyses, the association of urinary iodine and methylmalonic acid from healthy volunteers will be assessed between untreated sample and a sample expressed from a sanitary napkin. Participants will be recruited based on their dietary pattern (omnivorous, vegetarian and vegans) to have a broad spectrum of analyte concentration. Participants weight, height, age, nutritional supplement use and diet will be assessed.
Study Type
OBSERVATIONAL
Enrollment
30
urinary iodine, creatinine and methylmalonic acid, iodine and vitamin B12 dietary intake from foods and supplements
University of Hohenheim
Stuttgart, Baden-Wurttemberg, Germany
Correlation untreated and expressed urine
Correlation of creatinine, methylmalonic acid and iodine between unprocessed urine and urine expressed from a sanitary diaper to evaluate possible matrix effects on analytes.
Time frame: 8-9 weeks after completion
Correlation of urinary biomarkers with food and supplement intake
Correlation of dietary intake assessed by a food frequency questionnaire with urinary iodine and methylmalonic acid normalized to creatinine.
Time frame: 8-9 weeks after completion
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