Effect of Different VV ECMO Flows on Lung Perfusion Monitored by EIT

Union Hospital, Tongji Medical College, Huazhong University of Science and Technology15 enrolled

Overview

The purpose of this study is to investigate the feasibility of using electric impedance tomography (EIT) to monitor lung perfusion during veno-venous (VV) extracopreal membrane oxygenation (ECMO) support, as well as the effect of different ECMO flows on lung perfusion monitored by EIT.

This is a monocentric obsevensional study that uses EIT to monitor lung perfusion during VV ECMO support and the effect of different ECMO flows on lung perfusion as measured by EIT. Patients on VV ECMO who meet the withdrawal criteria as determined by clinical experts will have their ECMO flow gradually reduced. EIT lung ventilation and perfusion monitoring were performed at various ECMO flows.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Critical Illness

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Patients aged ≥ 18 and ≤ 70 years； 2. Patients supported with VV ECMO for respiratory failure； 3. Patients are intubated and mechanically ventilated. Exclusion Criteria: 1. EIT contraindications such as chest wound dressing, pacemaker installation, defibrillator, etc; 2. Patients who did not sign the informed consent form; 3. Pulmonary embolism; 4. Pneumothorax; 5. Medium to plenty of chest water; 6. Atrial fibrillation or other malignant arrhythmia leads to a decrease in cardiac output; 7. Refractory shock; 8. Severe chronic heart and lung disease has existed in the past; 9. BMI\>35 kg/m2; 10. Intra-abdominal pressure \>20mmHg.

Locations (1)

Xiaobo Yang

Wuhan, Hubei, China

RECRUITING

Outcomes

Primary Outcomes

Lung perfusion at different VV ECMO flows

Effect of Different VV ECMO Flows (ECMO flow at 4.5L,3.5L,2.5L,1.5L, and after ECMO withdrawal) on lung perfusion distribution Monitored by EIT

Time frame: up to 24hour

Secondary Outcomes

Lung ventilation at different VV ECMO flows

Effect of Different VV ECMO Flows (ECMO flow at 4.5L,3.5L,2.5L,1.5L, and after ECMO withdrawal) on lung ventilation distribution monitored by EIT

Time frame: up to 24hour

Lung deadspace region at different VV ECMO flows

Effect of Different VV ECMO Flows (ECMO flow at 4.5L,3.5L,2.5L,1.5L, and after ECMO withdrawal) on lung deadspace region monitored by EIT

Time frame: up to 24hour

Lung shunt region at different VV ECMO flows

Effect of Different VV ECMO Flows (ECMO flow at 4.5L,3.5L,2.5L,1.5L, and after ECMO withdrawal) on lung shunt region monitored by EIT

Time frame: up to 24hour

Lung ventilation/perfusion matching at different VV ECMO flows

Effect of Different VV ECMO Flows (ECMO flow at 4.5L,3.5L,2.5L,1.5L, and after ECMO withdrawal) on lung ventilation/perfusion matching monitored by EIT

Time frame: up to 24hour

Recirculation at different VV ECMO flows

Recirculation at different VV ECMO flows (ECMO flow at 4.5L,3.5L,2.5L,and1.5L)

Time frame: up to 24hour

Central Contacts

Xiaobo Yang, prof.

CONTACT

008602785351606 want.tofly@aliyun.com

You Shang, prof.

CONTACT

008602785351607 you_shanghust@163.com

Data from ClinicalTrials.gov

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