50 patients of both sexes undergoing elective CABG surgery will be randomly divided into 2 groups, study group (Dex) group and control group (C) to determine the effect of dexmedetomidine on the peri-operative hemodynamic changes during CABG surgery.
The effect of dexmedetomidine during CABG surgery is studied regarding Ventricular function, pre bypass and post bypass using the transoeophageal echo (TEE), post-operative by transthoracic echocardiography (TTE) on day of surgery and after extubation. Incidence of intraoperative and post operative ischemia and arrhythmias using Electrocardiogram (ECG) as well as the length of ICU and hospital stay.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
TRIPLE
Enrollment
50
a central sympatholytic drug
saline is given to control group
Ain Shams University
Cairo, Abassia, Egypt
Intra-operative ventricular function.
global systolic function Ejection Fraction by TEE intraoperative
Time frame: Intraoperative
post-operative ventricular function.
global systolic function Ejection Fraction by TTE postoperative
Time frame: Up to 24 hours postoperative
hemodynamics
Heart Rate (beat/minute),
Time frame: Immediate postoperative and up to 24 hours postoperative
hemodynamics
Mean arterial blood pressure (mmHg)
Time frame: Immediate postoperative and up to 24 hours postoperative
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