Vitamin D in Healthy Adults After Strenuous Endurance Exercise

Taipei Medical University35 enrolled

Overview

The purpose of this study was to investigate the effects of vitamin D supplementation on biochemical response and aerobic capacity after strenuous endurance exercise (SEE).

All participants conducted a graded exercise test on an ergometric bicycle to determine the maximal oxygen consumption (VO2max) before and after supplementation, and the speed equivalent to 65% VO2max was conducted for a SEE test by ergometric bicycle for 2 hours, followed by increasing 100 RPM until exhaustion. Venous blood samples were drawn before, immediately after, 2-hour after, 4-hour after, 8-hour after, and 24-hour after the SEE test to determine the concentrations of biomarkers. Data was analyzed by Two-way mixed design ANOVA.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Healthy

Interventions

Vitamin DDIETARY_SUPPLEMENT

Participants received 5,000 IU of vitamin D orally twice daily for 4 weeks

Medium-chain triglyceridesDIETARY_SUPPLEMENT

Participants received the same amount of placebo matching vitamin D orally twice daily for 4 weeks

Eligibility

Sex: MALEMin age: 20 YearsMax age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * The volunteers included have conditions as stated below : 1. no history of cardiovascular, liver, kidney and diabetes disease 2. no acute sport injury 3. male adult whose concentration of 25(OH)D is under 30 ng/mL, and maximal oxygen consumption is over 40 ml/kg/min 4. did not participated in any clinical trials or research in the last 3 months before our experiment 5. no supplements were taken during the experimental period 6. were requested to maintain their regular daily life style and avoid alcohol intake Exclusion Criteria: * The volunteers were excluded if they have the situation stated below: 1. history of cardiovascular, liver, kidney and diabetes disease 2. acute sport injury 3. their concentration of 25(OH)D is over 30 ng/mL, or maximal oxygen consumption is under 40 ml/kg/min 4. participated in any clinical trials or experimental research in the last 3 months before our experiment 5. taking supplement during the experimental period 6. did not maintain their regular eating habit or drink alcohol

Locations (1)

Taipei Medical University

Taipei, Taiwan

Outcomes

Primary Outcomes

Concentration of Neutrophil

Time frame: before exercise

Concentration ofNeutrophil

Time frame: immediately after exercise

Concentration of Neutrophil

Time frame: 2-hour after exercise

Concentration of Neutrophil

Time frame: 4-hour after exercise

Concentration of Neutrophil

Time frame: 8-hour after exercise

Concentration of Neutrophil

Time frame: 24-hour after exercise

Concentration of eosinophil

Time frame: before exercise

Concentration of eosinophil

Time frame: immediately after exercise

Concentration of eosinophil

Time frame: 2-hour after exercise

Concentration of eosinophil

Time frame: 4-hour after exercise

Concentration of eosinophil

Time frame: 8-hour after exercise

Concentration of eosinophil

Time frame: 24-hour after exercise

Concentration of basophil

Time frame: before exercise

Data from ClinicalTrials.gov

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