What is the visible light protective effect of dihydroxyacetone in individuals with erythropoietic protoporphyria? This will be tested in this randomized blinded placebo controlled study.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Enrollment
6
Application of 10% dihydroxyacetone (2 mg per square cm skin)
Application of lotion to the skin (2 mg per square cm skin)
Ida Marie Heerfordt
Copenhagen, Denmark
RECRUITINGVisible light exposure dose to onset of first skin symptom
Assessed by phototesting
Time frame: Meassurement one day after dihydroxyacetone application
Change in skin color from before treatment to one day after treatment
Assessed by color scale. The color scale is presented in DOI: 10.1111/phpp.12458. It is a seven-point scale to assess skin color from light to dark. We expect that a large change in skin color will give the best effect.
Time frame: Meassurement of skin color just before dihydroxyacetone application and one day after application.
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