Dexmedetomidine Versus General Anesthesia on the Diagnosis of Endobronchial US-Guided Transbronchial Needle Aspiration

Kafrelsheikh University70 enrolled

Overview

The aim of this study is to compare dexmedetomidine as moderate sedation versus general anathesia on the diagnostic yield of Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration

Endobronchial ultrasound (EBUS)-guided transbronchial needle aspiration (EBUS-TBNA) has emerged as a highly effective, minimally invasive technique for sampling peribronchial, mediastinal, and lung masses for pathologic examination with low rate of complications, and costs. Dexmedetomidine, is a high-affinity adrenergic agonist of the alpha 2 receptor, is a potential alternative sedative. The use of dexmedetomidine does not lead to respiratory depression, or to a decline in cognitive skills or patient cooperation. This is because dexmedetomidine acts on the alpha-2 receptors in the locus coeruleus, in contrast to other sedatives (midazolam and propofol) which act on GABA receptors/cerebral cortex.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Sedation Dexmedetomidine EBUS Guided Transbronchial Needle Aspiration

Interventions

dexmedetomidinePROCEDURE

patients will recieve moderate sedation by dexmedetomidine as study group

general anesthesiaPROCEDURE

general anesthesia with neuromuscular blockade under controlled ventilation as control group.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * American Society of Anesthesiologists (ASA) physical status classification II or III a requiring EBUS-TBNA based on suspicion of either benign or malignant disease in mediastinal or hilar lymph nodes (LNs) or masses or requiring EBUS-TBNA for mediastinal staging of lung cancer. Exclusion Criteria: * Suspected need for additional procedures other than EBUS-TBNA during planned bronchoscopy (e.g., need for navigational bronchoscopy, endobronchial biopsies, and therapeutic bronchoscopy) * body mass index \> 35 kg/m2 * allergies to any of the involved sedatives or anesthetic agents * comorbidities contraindicating the EBUS procedure * pregnancy

Locations (1)

Mohammad Fouad Algyar

Tanta, ElGharbiaa, Egypt

Outcomes

Primary Outcomes

Diagnostic yield of Endobronchial ultrasound -guided transbronchial needle aspiration

The number of subjects in whom Endobronchial ultrasound -guided transbronchial needle aspiration provided a specific diagnosis will be assessed

Time frame: During procedure

Data from ClinicalTrials.gov

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