Bone metabolism and genetic characteristics of osteoporosis pedigree with kidney-yang deficiency
Families with or without osteoporosis of kidney-yang deficiency type will be included and compared with each other. Their genetic characteristics, bone changes, and TCM constitution are the focus of research.
Study Type
OBSERVATIONAL
Enrollment
600
Nankang Traditional Chinese Medicine Hospital
Gannan, Jiangxi, China
RECRUITINGNingxia Chinese medicine Rearch Center
Yinchuan, Ningxia, China
RECRUITINGLonghua Hospital, Shanghai University of TCM
Shanghai, China
RECRUITINGchanges in bone mineral density from baseline to 5 years after enrollment
lumbar (L1-4 as well as total) and hip bone mineral density will be recorded by dual energy X-ray absorptiometry
Time frame: at enrollment
changes in bone mineral density from baseline to 5 years after enrollment
lumbar (L1-4 as well as total) and hip bone mineral density will be recorded by dual energy X-ray absorptiometry
Time frame: 5 years after enrollment
Physical phenotype of traditional Chinese medicine
Occurrence of kidney yang deficiency
Time frame: at enrollment
Physical phenotype of traditional Chinese medicine
Occurrence of kidney yang deficiency
Time frame: 5 years after enrollment
Understand the general situation through the questionnaire
Including age（year）, sex（man,wowan）, height(cm), weight(kg), menstrual period,history of smoking and drinking, living habits, fracture history and risk assessment, skeletal muscle assessment, living environment, Chinese medicine constitution, etc
Time frame: at enrollment
Understand the general situation through the questionnaire
Including age（year）, sex（man,wowan）, height(cm), weight(kg), menstrual period,history of smoking and drinking, living habits, fracture history and risk assessment, skeletal muscle assessment, living environment, Chinese medicine constitution, etc
Time frame: 5 years after enrollment
Osteocalcin
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
serum osteocalcin
Time frame: at enrollment
procollagen type I N-terminal propeptide
serum procollagen type I N-terminal propeptide (PINP)
Time frame: at enrollment
Bone alkaline phosphatase
serum bone alkaline phosphatase (BALP)
Time frame: at enrollment
β-crosslaps
serum β-crosslaps (β-CTX)
Time frame: at enrollment
Ca
serum Ca
Time frame: at enrollment
P
serum P
Time frame: at enrollment
Mg
serum Mg
Time frame: at enrollment
Fibroblast growth factor
serum fibroblast growth factor (FGF)23
Time frame: at enrollment
Parathormone
serum parathormone (PTH)
Time frame: at enrollment
25(OH) vitamin D
serum total 25(OH) vitamin D
Time frame: at enrollment
Osteocalcin
serum osteocalcin
Time frame: 5 years after enrollment
Procollagen type I N-terminal propeptide
serum procollagen type I N-terminal propeptide (PINP)
Time frame: 5 years after enrollment
Bone alkaline phosphatase
serum bone alkaline phosphatase (BALP)
Time frame: 5 years after enrollment
β-crosslaps
serum β-crosslaps (β-CTX)
Time frame: 5 years after enrollment
Ca
serum Ca
Time frame: 5 years after enrollment
P
serum P
Time frame: 5 years after enrollment
Mg
serum Mg
Time frame: 5 years after enrollment
Fibroblast growth factor
serum fibroblast growth factor (FGF)23
Time frame: 5 years after enrollment
Parathormone
serum parathormone (PTH)
Time frame: 5 years after enrollment
25(OH) vitamin D
serum total 25(OH) vitamin D
Time frame: 5 years after enrollment
Gene testing(BGIseq T5,WGS)
Carry out whole-gene testing on the samples with obvious family heritability of osteoporosis, and analyze the differences at the gene level through sequencing compared with the control group
Time frame: at enrollment
Gene testing(BGIseq T5,WGS)
Carry out whole-gene testing on the samples with obvious family heritability of osteoporosis, and analyze the differences at the gene level through sequencing compared with the control group
Time frame: 5 years after enrollment