Vitamin D Supplementation in Healthy Adults in Prolonged Endurance Exercise

Taipei Medical University50 enrolled

Overview

The purpose of this study is to investigate the effects of vitamin D supplementation on biochemistry response and skeletal muscle synthesis in prolonged endurance exercise.

Endurance exercise mode will be used to evaluate the effects of vitamin D supplementation on cardiac biomarkers, metabolic hormones, oxidative damage, and inflammation responses. An independent samples and dose titration design will be used to assign 30 participants to the experimental group (n = 15) or placebo group (n = 15). All participants in the experimental group will have serum 25(OH)D concentrations higher than 48 ng/mL after supplementation period. After the prolonged endurance exercise test, the blood samples will be collected for analyzing biomarkers. Data will be analyzed by Two-way mixed design ANOVA.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Healthy

Interventions

Vitamin DDIETARY_SUPPLEMENT

Participants received 5,000 IU of vitamin D orally twice daily for 4 weeks. If the serum 25(OH)D concentration exceeds 48 ng/mL, the intervention remains the same. However, if the serum 25(OH)D concentration is under 48 ng/mL, the dosage would increase by 2,500 IU. The principle remains the same at week 6.

Medium-chain triglyceridesDIETARY_SUPPLEMENT

Participants received the same amount of placebo matching vitamin D orally twice daily.

Eligibility

Sex: ALLMin age: 20 YearsMax age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion criteria: * The volunteers included have conditions as stated below : 1. male adult between 20-40 years old without any history of cardiovascular, liver, kidney and diabetes disease 2. no acute sport injury 3. male adult whose concentration of 25(OH)D is under 30 ng/mL, and maximal oxygen consumption is over 40 ml/kg/min 4. did not participated in any clinical trials or research in the last 3 months before our experiment 5. no supplements were taken during the experimental period 6. were requested to maintain their regular daily life style and avoid alcohol intake Exclusion Criteria: * The volunteers were excluded if they have the situation stated below: 1. history of cardiovascular, liver, kidney and diabetes disease 2. acute sport injury 3. their concentration of 25(OH)D is over 30 ng/mL, or maximal oxygen consumption is under 40 ml/kg/mint 4. participated in any clinical trials or experimental research in the last 3 months before our experiment 5. taking supplement during the experimental period 6. did not maintain their regular eating habit or drink alcohol

Locations (1)

Taipei Medical University

Taipei, Taiwan

Outcomes

Primary Outcomes

Concentration of NT-proBNP

Time frame: before exercise

Concentration of NT-proBNP

Time frame: immediately after exercise

Concentration of NT-proBNP

Time frame: 2-hour after exercise

Concentration of NT-proBNP

Time frame: 24-hour after exercise

Concentration of cTnI

Time frame: before exercise

Concentration of cTnI

Time frame: immediately after exercise

Concentration of cTnI

Time frame: 2-hour after exercise

Concentration of cTnI

Time frame: 24-hour after exercise

Concentration of CK-MB

Time frame: before exercise

Concentration of CK-MB

Time frame: immediately after exercise

Concentration of CK-MB

Time frame: 2-hour after exercise

Concentration of CK-MB

Time frame: 24-hour after exercise

Concentration of CK

Time frame: before exercise

Data from ClinicalTrials.gov

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