The Influence of Testosterone on Experimental Pain Perception

Early Phase 1CompletedNCT05781685

University of New Mexico20 enrolled

Overview

This trial examined how the administration of exogenous testosterone would influence pain tolerance and other endogenous steroids (i.e. estradiol and progesterone).

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

OTHER

Masking

DOUBLE

Enrollment

Conditions

Acute Pain

Interventions

TestosteroneDRUG

Sublingual testosterone was administered to participants. Participants would self-administer the testosterone to themselves.

Placebo SyrupOTHER

Oil-based sublingual product.

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 25 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy college-aged females that are over the age of 18 and younger than 25 will be used for this study. Exclusion Criteria: * The following criteria will exclude a participant from the study: * Anyone that has a tree nut allergy. * Women that are pregnant or may feel that they may be pregnant or breast-feeding. * Anyone taking supplements that may influence their testosterone level. * Anyone taking any kind of steroid that may increase their testosterone level. * Anyone that smokes tobacco or uses smokeless tobacco. * Anyone that reports any condition associated with nerve damage. * Anyone that is using hormonal contraceptive. * Anyone who was sick or unwell at the time of screening. * Each participant completed a Testosterone Pre-Screen form. This form asked each participant individually whether they are taking any drugs or have any conditions that might be exacerbated by testosterone. This form was completed before they signed the consent form and each time they arrived in the lab for an experimental session.

Locations (1)

University of New Mexico

Albuquerque, New Mexico, United States

Outcomes

Primary Outcomes

Pain Tolerance

The ischemic discomfort task applied a sphygmomanometer (blood pressure cuff) 5 cm below their elbow. The cuff was inflated to 200 mmHg. Pain tolerance was measured by how long they could tolerate the ischemic discomfort task. However, task was only allowed to last for 6 minutes

Time frame: 4 hours After Administration

Secondary Outcomes

Changes Testosterone Levels

The measured testosterone levels in the participants before and after receiving the intervention

Time frame: Prior to Intervention (Baseline), 15 minutes Post Intervention

Changes Estradiol Levels

The measured estradiol levels in the participants before and after receiving the intervention.

Time frame: Prior to Intervention (Baseline), 15 minutes Post Intervention

Changes Progesterone Levels

he measured progesterone levels in the participants before and after receiving the intervention.

Time frame: Prior to Intervention (Baseline), 15 minutes Post Intervention

Data from ClinicalTrials.gov

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