Antithrombotic Therapy After Coronary Artery Bypass Grafting Combined With Coronary Endarterectomy

Inclusion Criteria: * Adult patients with diffuse coronary artery disease undergoing CE+CABG during the study period. * No contraindications for both dual antiplatelet therapy and anticoagulation therapy with warfarin. * Must be able to swallow tablets after the surgery. Exclusion Criteria: 1. Patients with high bleeding risk (HAS-BLED ≥ 3); 2. Patients undergoing concomitant aortic valve or mitral valve surgery, or undergoing cardiac surgery for the second time; 3. Emergency surgery; 4. Serum creatinine \>130μmol/L, or significant liver dysfunction (elevated ALT and/or AST); 5. History of digestive or urinary tract bleeding, active gastric bleeding caused by gastric ulcer, or postoperative new-onset gastric bleeding; 6. History of hemorrhagic stroke, or platelet dysfunction; 7. Allergic or with contraindication to any of aspirin, clopidogrel or warfarin; 8. Participated in other clinical trial for drug or device within 30 days; 9. Pregnant or planning to be pregnant.