Healthy Aging Through Dietary Intervention

Heinrich-Heine University, Duesseldorf68 enrolled

Overview

To test the impact of flavanol supplementation of cardiac and vascular function and subsequently on exercise capacity in elderly individuals

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

QUADRUPLE

Enrollment

Conditions

Aging, Healthy

Interventions

FlavanolDRUG

Assessement, supplementation for 30 days with either Placebo or Flavanols, Re-assessment

PlaceboDRUG

Assessement, supplementation placebo for 30 days with either Placebo or Flavanols, Re-assessment

Eligibility

Sex: ALLMin age: 50 YearsMax age: 79 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * age 50-79 Exclusion Criteria: * non-cardiac limitations of exercise capacity such as orthopedic or neurological disorders, BMI \>35 kg/m2, active smoking, uncontrolled blood pressure, diabetes, COPD, atrial fibrillation, cardiomyopathy, coronary heart disease, valvular heart disease, cardiac pacemaker, acute respiratory tract infections, missing ability or missing cooperation to participate in the study

Locations (1)

Heinrich Heine University

Düsseldorf, North Rhine-Westphalia, Germany

Outcomes

Primary Outcomes

Exercise capacity

maximum power output during cardiopulmonary exercise testing

Time frame: 30 days

peakVO2

maximum oxygen uptake during cardiopulmonary exercise testing

Time frame: 30 days

Secondary Outcomes

flow mediated vasodilation (FMD)

marker for vascular function

Time frame: 30 days

Oxygen pulse

oxygen uptake per heart beat (VO2/HR) as measured during cardiopulmonary exercise testing

Time frame: 30 days

aortic stiffness

cardiac magnetic resonance assessment of aortic diameter, distensibility and flow

Time frame: 30 days

diastolic strain

cardiac magnetic resonance (CMR) based assessment of left ventricular strain

Time frame: 30 days

Left ventricular function

systolic ejection fraction calculated based on magnetic resonance volumetric assessment of left ventricle

Time frame: 30 days

left atrial volume index (LAVi)

cardiac magnetic resonance based assessment of left atrial volume index

Time frame: 30 days

brain natriuretic peptide (nt-proBNP)

Data from ClinicalTrials.gov

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