The Effect of Colchicine on Food-related Effort-based Decision Making in Brain and Behaviour in Overweight and Obesity

Inclusion Criteria: * BMI ≥ 27 kg/m2 * Female sex * Right-handed * Age: 18-59 years * Shoulder width of \< 68 cm (to fit into the MRI scanner) * Dutch speaking - Sufficient level to understand task instructions * Low-grade inflammatory state, as measured by C-reactive protein (CRP) between 3.0 and 10.0 mg/L Exclusion Criteria: * Having been vaccinated by any type of vaccine in the 4 weeks preceding the first test session * Having had an infection characterized by a fever, or diagnosed by a medical physician in the 4 weeks preceding the first test session * Diagnosed with Diabetes Mellitus type I or II * Gained or lost \>2 points in BMI (kg/m2) over the last 6 months * Followed an energy restricting diet during the last 2 months * Having had bariatric surgery in the past 5 years * Regular use of anti-inflammatory, anti-diabetic, weight-loss, and psychoactive medication * Regular use of CYP3A4 inhibitors, P-glycoprotein inhibitors, statins, fibrates, ciclosporin, and digoxin, as a contraindication for colchicine * Have renal impairment as evidenced by serum creatinine \>150 μmol/l or eGFR \<50mL/min/1.73m2, determined maximum 12 weeks before inclusion * Have moderate to severe hepatic disease * (History of) clinically significant psychiatric or neurological disorder * (History of) clinically significant metabolic, cardiovascular, renal, liver, endocrinological, autoimmune or chronic inflammatory disease * General medical conditions, such as sensorimotor handicaps, deafness, blindness or colour-blindness, as judged by the investigator * Current or history of alcohol and/or drugs abuse (i.e. \>14 units per week) * Habitual smoking, i.e. one or more cigarettes per day * Pregnant, lactating or wishing to become pregnant in the period between the screening and until 3 months after the last study visit * Participation in another weight loss, lifestyle or anti-inflammatory intervention in the context of research at the time of inclusion or during the study * Contraindications for MRI