AminoMedixTM for Kidney Protection During Radionuclide Therapy

Inclusion Criteria: 1. Patients with neuroendocrine tumors are eligible to be recruited in this project. 2. Signed informed consent. 3. Patients of either gender, age 18 years or older. 4. Na+, K+, Cl,: within normal range 5. eGFR: \> 50 mL/min 6. Serum creatinine: \<150μmol/L. Serum creatinine: within normal range or \<120μmol/L for patients aged 60 years or older. 7. Negative pregnancy test (urine test or beta-HCG) in women capable of child-bearing. Exclusion Criteria: 1. Known hypersensitivity to Amifostine, Lysine, Arginine, DOTA, 68Gallium, to DOTATATE or to any of the excipients of 68Ga-DOTATATE. 2. Therapeutic use of any somatostatin analogue, including Sandostatin® LAR (within 28 days) and Sandostatin® (within 2 days) prior to study imaging. If a patient is on Sandostatin® LAR a wash-out phase of 28 days is required before the injection of the study drug. 3. Pregnant or breast-feeding women. 4. Current somatic or psychiatric disease/condition that may interfere with the objectives and assessments of the study. 5. Pre-existing cardiovascular or cerebrovascular conditions such as congestive heart failure, ischemic heart disease, arrhythmias, or a history of stroke or transient ischemic attacks. 6. Uncontrolled kidney disease and patients who are under dialysis. 7. Current treatment with potentially nephrotoxic drugs such as aminoglycosides. 8. Less than 24 hours of withdrawal of antihypertensive medications or uncontrolled hypertension, and diabetes at the time of the study. 9. Patients under total or partial parenteral nutrition.