An Exploratory Study on the Application of Transarterial CT Angiography in the Interventional Treatment of Massive Hemoptysis

Union Hospital, Tongji Medical College, Huazhong University of Science and Technology30 enrolled

Overview

This is a single-arm, exploratory study to evaluate the value of transarterial CT angiography applying Nexaris Angio-CT in the interventional treatment of massive hemoptysis

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Hemoptysis

Interventions

Transarterial CT angiographyDEVICE

Transarterial catheter-directed CT angiography during interventional treatment of hemoptysis

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with massive hemoptysis（defined as more than 100mL per session or more than 300mL/day or with acute respiratory failure requiring mechanical ventilation or hemodynamic instability (systolic blood pressure \< 90 mmHg), regardless of hemoptysis amount） Exclusion Criteria: * Pregnancy * Patients with a previous history of bronchial artery embolization * Uncorrectable severe infection, coagulation dysfunction, organ failure or cachexia, severe contrast agent allergy, and other interventional treatment contraindications

Locations (1)

Union Hospital affiliated to Tongji Medical College of Huazhong University of Science and Technology

Wuhan, Hubei, China

Outcomes

Primary Outcomes

The accuracy rate of transarterial CT angiography in the identification of culprit vessel

The accuracy rate of transarterial CT angiography in the identification of culprit vessel, by calculating the matching rate between Angio-CT and selective angiography findings.

Time frame: Intraoperative phase

In-hospital clinical success

either the complete cessation of hemoptysis or a clinically significant reduction in bleeding, defined as ≤ 5 mL/24 hours of blood-tinged sputum or fresh blood during the hospitalization period.

Time frame: During the postoperative hospitalization period (i.e., the period after bronchial artery embolization until discharge)

Early hemoptysis recurrence rate

Recurrence rate of hemoptysis within 3 months after treatment

Time frame: 3 months after treatment

Secondary Outcomes

Technical success rate

Technical success is defined as complete cessation of target blood flow confirmed by DSA

Time frame: Intraoperative phase

Radiation exposure

Radiation exposure data were systematically collected from structured radiation dose reports. For Angio-CT scans, radiation exposure was quantified using the volume CT dose index (CTDIvol) and dose-length product (DLP). For digital subtraction angiography (DSA) and fluoroscopy, air kerma (AK) and dose-area product (DAP) were utilized as metrics.

Time frame: Intraoperative phase

The amount of contrast agent consumed

The amount of contrast agent consumed during treatment

Time frame: Intraoperative phase

Data from ClinicalTrials.gov

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