The purpose of this study was to analysis the incidence of ear symptoms, cognitive function decline and emotional disorders in Chinese people who were infected with COVID-19, exploring the impact of COVID-19 on the auditory system, cognitive function and emotional function, and analyzing the changes in functional connectivity of brain network after COVID-19 infection.
Study Type
OBSERVATIONAL
Enrollment
30
Sun Yat-sen Memorial Hospital of Sun Yat-sen University
Guangzhou, Guangdong, China
The correlation between the peak of COVID-19 transmission and the popularity of related online terms
The correlation between the peak of COVID-19 transmission and the popularity of related online terms
Time frame: through study completion, an average of 3 months
Symptom incidence
According to the questionnaire survey of 748 patients, the incidence of hearing loss, tinnitus, ear tightness, earache, vertigo or other cognitive and emotional problems after COVID-19 was analyzed.
Time frame: through study completion, an average of 3 months
Pure tone average
According to the WHO grading standard of hearing loss in 1980, the average pure tone threshold (PTA) of 0.5k, 1k, 2k and 4kHz in better ears was defined as normal hearing, 26-40 dB HL(hearing level) was defined as mild hearing loss, and 41-55 dB HL was defined as moderate hearing loss. 56-70 dB HL was moderate to severe hearing loss, 71-90 dB HL was severe hearing loss, and ≥91 dB HL was extremely severe hearing loss.
Time frame: through study completion, an average of 3 months
Mini-Mental State Examination score and grade
There are 30 points in the Mini-Mental State Examination (MMSE) scale. The score of 27-30 is normal, and 21-26 is mild dementia. 10-20 is moderate dementia; On a scale of 0 to 9, dementia is severe
Time frame: through study completion, an average of 3 months
Montreal Cognitive Assessment score and grade
The total score of the Montreal Cognitive Assessment (MoCA) scale is 30 points, generally ≥26 points normal, 18-26 points mild cognitive impairment, 10-17 points moderate cognitive impairment, and \< 10 points severe cognitive impairment.
Time frame: through study completion, an average of 3 months
Pittsburgh Sleep Quality Interview score and grade
Pittsburgh Sleep Quality Index (PSQI) Scale total scores 21 points. A score of 0-5 indicates good sleep quality; A score of 6-10 indicates good sleep quality; 11-15 points, indicating average sleep quality; A score of 16 to 21 indicates poor sleep quality
Time frame: through study completion, an average of 3 months
Hamilton depression score and grade
For the 24th version of Hamilton depression Scale (HAMD), the total score \> 35 May indicate severe depression; 21-35, may be mild to moderate depression; 9-20, suspected depression; \< 8 indicates normal.
Time frame: through study completion, an average of 3 months
Resting state of Electroencephalogram data
Electroencephalogram (EEG) data of the study were preprocessed and trends in functional brain network connectivity were analyzed.
Time frame: through study completion, an average of 3 months
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