A Safety, Tolerability and Efficacy Study of NC525 in Subjects With Advanced Myeloid Neoplasms

Inclusion Criteria: 1. The subject is willing to provide written informed consent for the trial. 2. Be ≥ 18 years of age on the day of signing informed consent. 3. Subject has one of the following Myeloid Neoplasms determined by pathology review at the treating institution: 1. Relapsed or Refractory AML, Note: Active, relapsed, or refractory AML is defined as any one of the following: * Primary induction failure, or (PIF) after 2 or more cycles of therapy, * First early relapse after a remission duration of fewer than 6 months, * Relapse refractory to salvage combination chemotherapy second or subsequent relapse, or * Relapsed or refractory AML with at least 5% blasts by bone marrow biopsy or aspirate, or at least 1% blasts in peripheral blood. 2. Relapsed or Refractory Myelodysplastic syndrome (MDS) after prior hypomethylating agents. Note: Subject must have sub-type MDS-EB2 with 10-19% blasts by bone marrow biopsy or aspirate. 3. Relapsed or Refractory Chronic myelomonocytic leukemia (CMML) with progressive disease or lack of response to hypomethylating agents 4. A male subject must agree to use approved contraception (based on institutional guidelines) and refrain from sperm donation or expecting to father a child, from Screening through the treatment period and for at least 90 days after the last dose of study treatment. 5. A female subject is eligible to participate if she is not pregnant, not breastfeeding, and at least one of the following conditions applies: 1. Not a woman of childbearing potential (WOCBP); 2. A WOCBP agrees to follow approved contraceptive guidance (based on institutional guidelines) from Screening through the treatment period and for at least 90 days after the last dose of study treatment. 6. Have an Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 2. 7. Life expectancy greater than or equal to 12 weeks as judged by the Investigator. 8. Have adequate organ function as defined in the protocol. Exclusion Criteria: 1. Has a diagnosis of acute promyelocytic leukemia (M3, APL), accelerated phase or blast crisis of chronic myeloid leukemia. 2. History or presence of clinically relevant CNS pathology such as epilepsy, childhood or adult seizure, paresis, aphasia, stroke, severe brain injuries, dementia, Parkinson's disease, cerebellar disease, organic brain syndrome, or psychosis. 3. Patients with active Central Nervous System (CNS) involvement (such as leukemic infiltration, blast in the spinal fluid, or subjects with extramedullary disease). 4. A WOCBP who has a positive pregnancy test (within 72 hours) prior to treatment. 5. History or evidence of any other clinically significant disorder, condition or disease (e.g., symptomatic congestive heart failure, unstable angina pectoris, symptomatic myocardial infection, uncontrolled cardiac arrhythmia, pericardial disease or heart failure New York Heart Association Class III or IV), or severe debilitating pulmonary disease, that would potentially increase patients' risk for toxicity and in the opinion of the Investigator, would pose a risk to patient safety or interfere with the study evaluation, procedures or completion. 6. Chronic respiratory disease or any other medical condition that requires continuous oxygen that in the opinion of the Investigator, would adversely affect his/her participation in this study. 7. Has received a live or live-attenuated vaccine within 30 days prior to the first dose of study intervention. 8. Is currently participating in or has participated in a study of the following prior to the first dose of study treatment: 1. An investigational biologic or an investigational device within 4 weeks or 5 half-lives (whichever is longer); 2. An investigational oral agent within 2 weeks or 5 half-lives (whichever is shorter). 9. Has not recovered to ≤ Grade 1 from toxic effects of prior therapy (including prior chemotherapy, immunotherapy and radiation therapy) and/or complications from interventions before starting therapy. 10. Has previously had an allogeneic solid organ transplant. 11. Autologous HSCT within 6 weeks before the start of study treatment. 12. Allogeneic HSCT within 6 months before the start of study treatment. 13. Any active acute or chronic graft-versus-host disease (GvHD), grade 2-4, or active chronic GvHD requiring systemic treatment. 14. Any systemic therapy (e.g. calcineurin inhibitors (CNI), steroids, etc.) against GvHD within 4 weeks before the start of study treatment. 15. Any Grade ≥ 2 persistent non-hematological toxicity related to allogeneic transplant, such as those requiring systemic immunosuppressive therapy. 16. Previous CAR-T therapy. 17. Known concurrent malignancy that is progressing or requires active treatment, or history of other malignancy within 2 years of study entry after treatment with curative intent. 18. Has severe hypersensitivity (≥ Grade 3), known allergy or reaction to Immunoglobulins or NC525, and/or any of their excipients. 19. Uncontrolled systemic fungal, bacterial, viral, or other infection despite appropriate anti-infection treatment at the time of eligibility confirmation. 20. Has a known history of HIV infection. 21. Has a known active chronic hepatitis B infection or chronic hepatitis C infection with the exception of those with an undetectable viral load within 3 months. 22. Has a history or current evidence of any condition, therapy, or laboratory abnormality, or other circumstance that might confound the results of the study or interfere with the subject's participation for the full duration of the study, such that it is not in the best interest of the subject to participate, in the opinion of the treating investigator. 23. Has a known psychiatric or substance abuse disorder that would interfere with the subject's ability to cooperate with the requirements of the study.