Efficacy and Neuroimaging Mechanisms of Smoking Cessation in China

Inclusion Criteria: 1. Use cigarettes for no less than 1 year, and use cigarettes ≥ 10 per day 2. Nicotine dependence (FTCD ≥ 3) 3. Willing to make an attempt to quit smoking in the next month, and have not quit smoking in the past 3 months, and . 4. No other addictions except nicotine 5. Education level of junior high school or above 6. Age between 18 to 45 years old 7. Right-handed 8. No contraindication of MRI scanning 9. Willing to provide informed consent to participate in the study. Exclusion Criteria: 1. Patients who are receiving medication 2. Previous and current mental disorders,and/or mental disorders in line with DSM-5 diagnostic criteria in two departments and three generations. 3. Brain organic disease, brain injury history, coma history 4. Serious physical disease, endocrine disease history, abnormal blood picture, heart, liver and kidney function after examination 5. Pregnant and lactating women