Septic arthritis (SA) is a rare but highly disabling disease. The ideal diagnosis criteria is not well established. There is an urgent need to establish golden standard for diagnosis.
Septic arthritis (SA) is a rare but highly disabling disease. Epidemiologic studies have documented an incidence of 0.9-1.3 per 100,000 \[1, 2\]. The treatment is challenging and the ideal diagnosis criteria is not well established. The specific tactics employed by relevant researches varied widely \[3-6\]. Patients with recurrent sepsis may require arthrodesis or amputation, which would result in severe functional loss \[2\]. Therefore, there is an urgent need to establish golden standard for diagnosis.
Study Type
OBSERVATIONAL
Enrollment
400
including white blood cell count, C-reactive protein, erythrocyte sedimentation rate, percent of polymorphonuclear leukocytes, albumin, and globulin
including fever, joint pain, local swelling and redness, sinus
including arthrocentesis culture，and frozen section
The First Affiliated Hospital of Zhejiang Chinese Medical University
Hangzhou, Zhejiang, China
RECRUITINGZhejiang hospital
Hangzhou, Zhejiang, China
RECRUITINGWBC counts
white blood cell (WBC) counts
Time frame: preoperatively
%PMN
percent of polymorphonuclear leukocytes (%PMN)
Time frame: preoperatively
CRP
concentration of C-reactive protein (CRP)
Time frame: preoperatively
ESR
erythrocyte sedimentation rate (ESR)
Time frame: preoperatively
Albumin
concentration of albumin
Time frame: preoperatively
Globulin
concentration of globulin
Time frame: preoperatively
Body temperature
to check whether there has been a fever (\>37.2°C) previously or now by medical history consultation and physical examination
Time frame: preoperatively
joint swelling and redness
to check whether there is joint swelling and redness by visual inspection and palpation
Time frame: preoperatively
sinus tract
to check whether there is any sinus tract by visual inspection
Time frame: preoperatively
positive X-ray findings
to determine whether there are positive X-ray findings, such as bone destruction, narrowing of the joint space, etc.
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Time frame: preoperatively
positive MR findings
to determine whether there are positive MR findings, such as joint effusion, cartilage damage, etc.
Time frame: preoperatively
positive pathological findings
determined by 5 or more neutrophils per high-power field on histopathologic examination
Time frame: intraoperatively
positive culture
determined by a bacterial growth when culture of blood or joint fluid in agarose
Time frame: preoperatively