Association of Oral Helicobacter Pylori Infection With Gastric Helicobacter Pylori Infection

Inclusion Criteria: 1. Age between 18\~70 ,both gender. 2. Initial diagnosis of stomach Helicobacter pylori infection or never had Helicobacter pylori infection. 3. Have not received dental care or systemic periodontal basic treatment in the past 1 year. Exclusion Criteria: 1. There is serious organ damage and complications (such as cirrhosis, uremia, etc.), severe or unstable cardiopulmonary or endocrine diseases. 2. Ongoing use of antiulcer medications (including PPIs taken within 2 weeks before Helicobacter pylori infection testing), antibiotics, or bismuth complexes (more than 3 times/week before screening). 3. Those with severe oral diseases and malignant tumors of the mouth. 4. Previously had upper gastrointestinal surgery. 5. Refusal to sign informed consent.