Effect of Oral Helicobacter Pylori Infection on the Efficacy of Gastroluminal Helicobacter Pylori Eradication Therapy

Inclusion Criteria: 1. Age between 18\~70 ,both gender. 2. Initial diagnosis of stomach Helicobacter pylori infection or never had Helicobacter pylori infection. 3. Have not received dental care or systemic periodontal basic treatment in the past 1 year. Exclusion Criteria: 1. Those who have contraindications to the drugs used in this institute or are allergic to the drugs used. 2. There is serious organ damage and complications (such as cirrhosis, uremia, etc.), severe or unstable cardiopulmonary or endocrine diseases. 3. Ongoing use of antiulcer medications (including PPIs taken within 2 weeks before Helicobacter pylori infection testing), antibiotics, or bismuth complexes (more than 3 times/week before screening). 4. Those with severe oral diseases and malignant tumors of the mouth. 5. Women planning pregnancy, pregnancy and breastfeeding. 6. Previously had upper gastrointestinal surgery. 7. Those who do not take their medication on time. 8. Refusal to sign informed consent.