Predictive Factors for Survival in Aggressive Meningiomas

Fondazione Policlinico Universitario Agostino Gemelli IRCCS250 enrolled

Overview

The investigators plan to collect clinical and molecular data, including ICH, PCR, NGS and methylome, from patients operated on for grade 2 or grade 3 meningioma. The purpose of the study is to identify reliable and easy-to-assess predictive factors for recurrence and survival after surgery.

Study Type

INTERVENTIONAL

Allocation

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

250

Conditions

Meningioma Meningioma Atypical Anaplastic Meningioma

Interventions

Biological biomarker assessmentDIAGNOSTIC_TEST

IHC, PCR, NGS, methylome

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Patient operated for atypical (grade 2) meningioma; or 2. Patient operated for anaplastic (grade 3) meningioma; 3. Timeframe for surgery, 1999-2019 Exclusion criteria 1\) Patient lost at follow-up

Locations (1)

Fondazione Policlinico Universitario A. Gemelli IRCCS

Rome, Italy

RECRUITING

Outcomes

Primary Outcomes

Recurrence-free survival (RFS)

Correlation from biomolecular data and RFS

Time frame: 5 years on average

Secondary Outcomes

Overall survival (OS)

Correlation from biomolecular data and OS

Time frame: 5 years on average

Central Contacts

Alessandro Olivi, MD

CONTACT

+39 06 3015 4120 alessandro.olivi@policlinicogemelli.it

Rina Di Bonaventura, MD

CONTACT

+39 06 3015 1 rina.dibonaventura@guest.policlinicogemelli.it

Data from ClinicalTrials.gov

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