Single-center Prospective Study of Non-invasive Methods for the Diagnosis of Postoperative Complications in Liver Transplant Recipients

Fondazione Policlinico Universitario Agostino Gemelli IRCCS100 enrolled

Overview

A lot of different early and late complications may occur after liver transplantation. They could be related to surgical procedure, to infectious diseases or immuno-mediated diseases (acute cellular rejection, ACR). Almost all of those complications are characterized by an elevation in liver enzymes (ALT, AST and GGT) and a decline of liver function tests (serum bilirubin and INR increase) possibly leading to early allograft disfunction (EAD). In this scenario there is a lack of biomarker that could predict the development of ACR and/or EAD. The aim of this study is to explore the prognostic role of non-invasive instrumental and biological marker in the early post-transplant phase.

Study Type

OBSERVATIONAL

Enrollment

100

Conditions

Rejection Acute Hepatic Transplant; Failure, Liver Liver Dysfunction

Eligibility

Sex: ALLMin age: 18 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients eligible for liver transplantation following National and International Guidelines Exclusion Criteria: * No agreement or inability to give informed consent * Re-transplant patients * Liver transplant in fulminant hepatitis

Locations (1)

Outcomes

Primary Outcomes

Early Allograft dysfunction (EAD)

Olthoff criteria: bilirubina≥ 10 mg/dL in 7th post-operative day, international normalized ratio (INR) ≥ 1.6 in 7th post-operative day 7; ALT or AST\> 2000 IU/L during the first 7 days after liver transplantation

Time frame: 2 weeks from Liver transplantation