To develop and validate a tool that estimates the degree of pregnancy-associated progression of renal disease in women with CKD and pregnancy outcomes in an international multicentre cohort study.
The aim of this study is to develop and validate a tool that estimates the degree of pregnancy-associated progression of renal disease in women with CKD and pregnancy outcomes in an international multicentre cohort study. Two prediction models will be developed to estimate the likelihood of both outcomes. The models will be developed and internally validated in one cohort in the United Kingdom and then externally validated using four international datasets.
Study Type
OBSERVATIONAL
Enrollment
5,000
Primary outcome a 25% or greater decline in eGFR between six weeks and 12 months postpartum or initiation of dialysis
A \>=25% reduction in eGFR between six weeks and 12 months postpartum or initiation of dialysis.
Time frame: Six weeks to 12 months postpartum
Secondary outcome: a preterm birth less than 34 weeks or small for gestational age less than 3rd percentile.
A composite outcome of preterm birth defined as less than 34 weeks gestation and/or SGA \< 3rd percentile.
Time frame: To be recorded within 24 hours of date of delivery (Index event is the day of delivery). This outcome is measured on date of delivery.
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