Effects of Permissive Hypercapnia on Concentration of Postoperative Plasma Neurofilament Light

Affiliated Hospital of Jiaxing University84 enrolled

Overview

The aim of this study is to conduct a prospective, single-center randomized controlled study to investigate the changes of plasma NFL concentration in patients undergoing laparoscopic surgery with mild hypercapnia, and further explore its impact on the central nervous system.

Plasma NFL concentrations were measured preoperatively and 1 day postoperatively. Secondary endpoints:CAM (Confusion Assessment Method) is conducted to check the subjects' baseline cognitive function preoperative day and 1 day postoperatively to assess whether delirium occurs.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Hypercapnia

Interventions

permissive hypercapniaBEHAVIORAL

Tidal volume (6-8ml/kg) and respiratory rate is adjusted to achieve the objective values of PaCO2:45～55mmHg

normocapniaBEHAVIORAL

Tidal volume (8-10ml/kg) and respiratory rate is adjusted to achieve the objective values of PaCO2:35～45mmHg

Eligibility

Sex: ALLMin age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: * age over 60 years * duration of pneumoperitoneum greater than 60 minutes * American Society of Anesthesiology (ASA) status Ⅱ-Ⅲ * undergoing laparoscopic surgery under general anesthesia with endotracheal intubation Exclusion Criteria: * history of mental or neurological disorders * preoperative use of antipsychotic drugs * American Society of Anesthesiology (ASA) status Ⅳ * severe abnormalities in heart, lung, liver, kidney, and coagulation function * Intracranial space-occupying lesions or major cerebrovascular diseases (such as carotid atherosclerosis and cerebral aneurysm) * Severe hypertension or hypotension * Severe metabolic acidosis or hypercapnic respiratory failure before surgery

Locations (1)

Affiliated Hospital of Jiaxing University

Jiaxing, Zhejiang, China

Outcomes

Primary Outcomes

Changes in plasma Neurofilament Light levels

Comparison of changes in plasma Neurofilament Light levels pre and postoperative in patients exposed and not exposed to hypercapnia.

Time frame: 1 week

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.