This trial investigates the effect of BurstDR and tonic spinal cord stimulation (SCS) on glucose metabolism and heart rate variability in patients with neuropathic pain.
This study investigates the effect of spinal cord stimulation (BurstDR stimulation versus tonic stimulation versus no stimulation) on glucose metabolism, insulin secretion and heart rate variability in patients with neuropathic pain. To assess insulin secretion, hyperglycaemic clamps are performed in 10 patients. Three different stimulation conditions (BurstDR, tonic and no stimulation) are tested in 10 hyperglycaemic clamps each. A total of 30 clamps are carried out.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
BurstDR spinal cord stimulation
Tonic spinal cord stimulation
Stimulator is switched off
University Hospital Tuebingen
Tübingen, Germany
First and second phase of insulin secretion
Modulation of insulin secretion by spinal cord stimulation
Time frame: Insulinsecretion during clamp (2 hours)
Root Mean Square of Successive Differences (RMSSD)
Modulation of heart rate variability by spinal cord stimulation assessed by electrocardiography
Time frame: Heart rate variablity during stimulation (10 minutes)
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