Multi-omics Study of Tongue Coating in Malignant Tumors of Digestive Tract

Inclusion Criteria: 18≤age≤80. Histologically or cytologically confirmed malignant tumor. No prior chemotherapy, radiotherapy, biotherapy, immunotherapy or other anti-tumor treatment for malignant tumor. Subject volunteers to join the study, signs informed consent, has good compliance and can cooperate with follow-up. Exclusion Criteria: Two or more kinds of malignant tumors at the same time. Malignant tumor that has been treated by chemotherapy, radiotherapy, biotherapy, immunotherapy or other anti-tumor therapy. Subjects who had other factors that might force them to terminate the research ahead of time, such as the development of other severe disease (including mental disease) that required combined treatment, seriously abnormal laboratory examination value, and family or social factors that might affect the subject safety or experimental data collection, as judged by the researchers.