Post-thrombotic syndrome (PTS) is the most frequently observed chronic complication of deep vein thrombosis (DVT), with an estimated cumulative incidence of 20-50%. Endovascular venous recanalization with angioplasty and stenting of obstructive lesions is the recommended treatment option to reduce or correct the symptoms of DVT. However, its impact on the physical capacity and breathlessness of patients has not been fully demonstrated. The heterogeneous evidences of clinical improvement is probably related to the presence or absence of collateral veins developed in these patients with proximal venous obstruction (iliac or iliofemoral with or without inferior vena cava involvement), which ensure the cardiac venous return. The aim of this study is to compare changes in maximal oxygen uptake after endovascular venous recanalization in DVT patients and to evaluate the hemodynamic, respiratory and muscular improvement induced by the restoration of venous flow in the occluded segments.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
OTHER
Masking
NONE
Enrollment
22
Diagnostic Test: * Maximum effort test (CPET) on a cycloergometer * Leg muscle strength assessment * Leg muscle mass, composition and water compartments (segmental bioelectrical impedance) * Spirometry, arterial blood gaz, NO/CO transfer
Hopital Arnaud de Villeneuve - CHU de Montpellier
Montpellier, France
VO2 max
Change in VO₂ max is the maximum (max) rate (V) of oxygen (O₂) the body is able to use during exercise from baseline to 8 weeks. It is measured in liters of O2 per minute
Time frame: From baseline and 8 weeks
Maximum aerobic power (in Watts)
Maximum aerobic power is measured in watts before and after venous recanalization
Time frame: From baseline and 8 weeks
Isowork power
The isowork power is the power output assessed at the V'O2max before recanalization
Time frame: From baseline and 8 weeks
Maximal exercise cardiac output (in litres per minute)
Maximal exercise cardiac output is the cardiac output assessed by thoracic impedance et peak exercise before and after venous recanalization
Time frame: From baseline and 8 weeks
Exercise change in Inspiratory capacity (in litres)
Exercise change in Inspiratory capacity is the change between rest and peak exercise of the inspiratory capacity (the volume between end-expiratory volume and total lung capacity) before and after venous recanalization
Time frame: From baseline and 8 weeks
Maximal exercise capillary volume (in millilitres)
Maximal exercise capillary volume is the capillary volume at peak exercise assessed by NO/CO transfer before and after venous recanalization
Time frame: From baseline and 8 weeks
Maximal exercise O2 arterial pressure (PaO2, in mmHg)
Maximal exercise O2 arterial pressure is the oxygen partial pressure in the arterial blood, assessed at peak exercise, before and after venous recanalization
Time frame: From baseline and 8 weeks
Maximal isometric torque during leg extension (in Newton.meters)
Maximal isometric strength during leg extension is the maximal torque of the leg extension at 90° knee flexion assessed by a torque sensor before and after venous recanalization
Time frame: From baseline and 8 weeks
Lower limb extracellular/total water (in %)
Lower limb extracellular/total water is the water volume int the body compartments in each lower limb, assessed by a segmental bioelectrical impedancemeter before and after venous recanalization
Time frame: From baseline and 8 weeks
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