Delayed Dinner, Exercise and Glucose Metabolism

National Taiwan Normal University12 enrolled

Overview

This study aims to investigate whether exercise can alleviate the impact of delayed dinner on metabolic health next morning in sedentary healthy adults

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Normal Dinner Delayed Dinner Exercise Plus Delayed Dinner

Interventions

Normal dinnerBEHAVIORAL

Participants will consume breakfast at 0830-0855 am, lunch at 1230-1255 pm, followed by dinner at 1800-1825 pm. Snacks will be consumed at 2130-2140 pm.

Delayed dinner consumptionBEHAVIORAL

Participants will consume breakfast at 08:30-08:55 am, lunch at 12:30-12:55 pm, followed by snacks at 18:00-18:10 pm. Dinner will be consumed at 21:30-21:55 pm.

Exercise with delayed dinner consumptionBEHAVIORAL

Participants will consume breakfast at 08:30-08:55 am, lunch at 12:30-12:55 pm, followed by snacks at 18:00-18:10 pm. Participants will exercise for 45 min at moderate-intensity 45 min prior to the delayed dinner at 21:30-21:55 pm.

Eligibility

Sex: MALEMin age: 20 YearsMax age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Physical inactive males * Weight stable for more than 3 months (no change in weight +/- 3%) * Non-smoker * Able to walk comfortably on a treadmill * Dinner consumers with normal sleep pattern (cycles) Exclusion Criteria: * Personal history of/existing diabetes, cardiovascular disease, metabolic disease or dyslipidaemia * Taking medications that may influence lipid or carbohydrate metabolism or immune system function * Unable to take part in exercise for any reason (e.g., injury or disability) or a positive response to any questions on the Physical Activity Readiness questionnaire (PAR-Q)

Locations (1)

National Taiwan Normal University

Taipei, Taiwan

RECRUITING

Outcomes

Primary Outcomes

Metabolic health (Oral glucose tolerance test, OGTT)

Fasting and postprandial blood glucose responses on next morning between trials

Time frame: 120 minutes

Metabolic health (Oral glucose tolerance test, OGTT)

Fasting and postprandial blood insulin responses on next morning between trials

Time frame: 120 minutes

Secondary Outcomes

Inflammation

Fasting inflammatory biomarkers (IL-6, TNF-a, CRP) on next morning between trials

Time frame: Baseline

Visual analogue scale (VSA)

Changes in VAS from 0-100 mm (e.g., appetite \& mood, etc.) on next morning between trials

Time frame: 120 minutes

Substate oxidation

Lipid and carbohydrate oxidation during OGTT between trials

Time frame: 120 minutes

Blood pressure

Changes in blood pressure (systolic and diastolic blood pressure) on next morning between trials

Time frame: 120 minutes

Appetite (lunch intake)

Ab libitum energy intake on next morning by the end of trial

Time frame: 30 minutes

HRV

Heart rate variability on next morning between trial

Time frame: Baseline

Central Contacts

Yung-Chih Chen

CONTACT

+886277496979 yc.chen@ntnu.edu.tw

Chen

CONTACT

yc.chen@ntnu.edu.tw

Data from ClinicalTrials.gov

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