In patients suffering from anorexia nervosa associated with severe major depression, serotonin reuptake inhibitor drugs have shown little efficacy in significantly reducing depressive symptoms. A possible explanation for this poor efficacy could be that people with anorexia nervosa have a deficiency in amino acids such as tryptophan, which is necessary for the production of the neurotransmitter serotonin. Therefore, tryptophan supplementation has been suggested as a means of increasing the pharmacological response to serotonin reuptake inhibitor drugs in patients with anorexia nervosa. Furthermore, malnutrition present in patients suffering from anorexia nervosa is in some cases associated with problems of intestinal absorption of nutrients, with possible implications on the pharmacokinetics of the drugs administered, including selective serotonin reuptake inhibitors (SSRIs). The present observational study aims to evaluate the correlations between the clinical response to Citalopram therapy (in different o.s. and i.v. formulations) and some nutritional, neurotransmitter and inflammatory biomarkers, in order to identify potential predictive markers of response to therapy for severe major depression in patients with anorexia nervosa. The following parameters will be evaluated in patients enrolled in all 3 observation times described above: * Plasma concentration of Citalopram * Serum concentration of Serotonin * Plasma concentration of dopamine * Serum concentration of Tryptophan * Serum concentration of BDNF * Hamilton scale 17 items and other clinical scales (EDI-3, SCL-90, BUT).
Study Type
OBSERVATIONAL
Enrollment
123
Citalopram: i.v.: 10 mg/die for day 1-7, 20 mg/die for day 8-14 p.o.: 20 mg/die for day 15-28
Citalopram: p.o: 10 mg/die for day 1-7, 20 mg/die for day 15-28
Istituto Auxologico Italiano
Oggebbio, Italy
RECRUITINGChange in Hamilton Depression Rating Scale
17-item Hamilton Depression Rating Scale -
Time frame: At baseline, 2 weeks and 4 weeks after treatment with citalopram
Change in plasma level of citalopram
Plasma level of citalopram
Time frame: At baseline, 2 weeks and 4 weeks after treatment with citalopram
Change in plasma level of dopamine
Plasma level of dopamine
Time frame: At baseline, 2 weeks and 4 weeks after treatment with citalopram
Change in serum level of serotonin
Serum level of serotonin
Time frame: At baseline, 2 weeks and 4 weeks after treatment with citalopram
Change in serum level of brain-derived neurotrophic factor
Serum level of brain-derived neurotrophic factor
Time frame: At baseline, 2 weeks and 4 weeks after treatment with citalopram
Change in serum level of tryptophan
Serum level of tryptophan
Time frame: At baseline, 2 weeks and 4 weeks after treatment with citalopram
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.