PET-MRI Esophagus Feasibility Study

University Health Network, Toronto15 enrolled

Overview

This is a single arm, single centre, investigator initiated study to investigate the feasibility of using PET-MRI imaging in radiation treatment workflow in up to 15 patients with esophagogastric cancer. PET-MRI imaging will be completed before the start of radiation treatment. MRI imaging will be completed during radiation treatment and after radiation treatment. These images will not be used to plan the radiation treatment and routine clinical care will be provided. The goal of this study is to gather information that will allow the radiation team to include MRI and PET imaging into the radiation treatment workflow for patients with esophageal cancer receiving radiation therapy in the future.

Study Type

INTERVENTIONAL

Allocation

Purpose

HEALTH_SERVICES_RESEARCH

Masking

NONE

Enrollment

Conditions

Esophagogastric Cancer

Interventions

A PET/MRI scan is a two-in-one test that combines images from a positron emission tomography (PET) scan and a magnetic resonance imaging (MRI) scan. Magnetic Resonance Imaging (MRI) provides better soft tissue contrast compared to conventional computerized tomography (CT), and when combined with PET, can potentially provide better visualization of the tumor shape, size, and position. Additional MRI imaging will be completed once during radiation treatment, and once after radiation treatment

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients 18 years or older * Diagnosed with locally advanced esophageal cancer being considered for conventional RT \>4 weeks * Ability and willingness to provide written informed consent Exclusion Criteria: * Contraindication for MRI * Contraindication for Gadolinium (i.e. inability to lie supine for at least 60 minutes) * Any patient who is pregnant or breastfeeding * Pacemaker or implanted defibrillator * Claustrophobia

Outcomes

Primary Outcomes

Feasibility of PET-MRI to visualize and assess impact of RT treatments on esophagogastric tumors

Detection of metastases on DWI and gadolinium enhanced T1-weighted 3D VIBE sequences.

Time frame: 2 years

Secondary Outcomes

Difference in manual GTV segmentation using PET-MRI

Differences in manual GTV segmentation between standard of care treatment plan and study generated treatment plan using PET-MRI.

Time frame: 2 years

Quantification of dosimetric advantages of PET-MRI treatment plan

Comparison of dosimetry properties between the standard of care treatment plan and study generated treatment plan using PET-MRI.

Time frame: 2 years

PET-MRI Esophagus Feasibility Study

Overview

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Secondary Outcomes

Central Contacts