Adipose-derived Stem Cells to Treat Chronic Wounds.

Inclusion Criteria: 1. Subject must agree to adhere to all protocol procedures and return for weekly scheduled wound assessment visits, including requirements for taking and abstaining from medications. 2. Subject is willing and able to read, understand and sign a written Informed Consent to participate in the study or have an appropriate representative available to do so. 3. Subject must have a full thickness Stage III or Stage IV pressure ulcer, deep venous ulcer, deep diabetic ulcer, ischemic ulcer, abdominal wound, nonhealing surgical site or sickle cell ulcer. For subjects with more than one wound that meet these criteria, the largest qualifying wound will be treated. 4. Subject has adequate (\>200 mL) abdominal or other subcutaneous adipose tissue accessible by syringe-based fat harvest and is able to undergo a fat harvest procedure in the opinion of the investigator or per facility guidelines and has activated platelet thromboplastin time (aPTT) within the normal reference range at the time of the fat harvest procedure and no contraindication to fat harvest. 5. Subject's wound has been refractory to standard of care (no objective/measureable signs of healing) for at least 30 days. Exclusion Criteria: 1. Subject has local infection with erythema \> 2 cm, or involving structures deeper than skin and subcutaneous tissues (e.g., abscess, osteomyelitis, septic arthritis, fasciitis), or associated with local wound complications such as prosthetic materials or protruding surgical hardware. 2. Subject has ≥ 2 of the following signs of systemic inflammatory response syndrome (SIRS) or septic shock within 7 days of screening: * Temperature \> 38°C or \< 36°C * Heart rate \> 90 beats/min * Respiratory rate \> 20 breaths/min or PaCO2 \< 32 mm Hg * White blood cell count \> 12,000 or \< 4,000 cells/μL or ≥ 10% immature (band) forms. 3. Subject has received biologic or cell therapy within 12 weeks of initiation of the study. 4. Subject not eligible for syringe-based liposuction of at least 200 mL of subcutaneous adipose tissue, including therapeutic anticoagulation with INR \>1.7 or PTT \>60, or receiving GIIb/IIIa inhibitors within 2 weeks prior to the study. 5. Subject has squamous cell carcinoma, basal cell carcinoma, melanoma or skin carcinoma of the affected limb or area and underwent treatment within the last year. 6. Subject is pregnant as determined by a positive pregnancy test prior to procedure, or breast-feeding. 7. Clinically significant abnormal findings on laboratory screening panels, including hemoglobin ≤10 g/dL. 8. Hepatic dysfunction, as defined as aspartate aminotransferase (AST), alanine aminotranferase (ALT), or bilirubin level \> 1.5 times the upper limit of normal range (x ULN) prior to randomization. 9. Chronic renal insufficiency as defined as a serum creatinine \> 2.0 mg/dL or requires dialysis. 10. History of organ transplantation.