To describe the molecular, electrophysiological and morphological expression profile of dopaminergic neurons derived from fibroblasts of patients with Parkinson's disease.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
OTHER
Masking
NONE
Enrollment
45
Punch biopsy of the skin
Flavia Torlizzi
Roma, Italy
RECRUITINGNeurophysiological characterization of dopaminergic neurons derived from patients with Parkinson's disease.
To evaluate the firing frequency in the dopaminergic neurons derived from fibroblasts of patients with Parkinson's disease.
Time frame: Baseline
Biochemical characterization of dopaminergic neurons derived from patients with Parkinson's disease.
To determine the amount of dopamine released from differentiated neurons derived from fibroblasts of patients with Parkinson's disease.
Time frame: Baseline
α-synuclein misfolding in dopaminergic neurons derived from patients with Parkinson's disease.
To document the presence of abnormal accumulation of misfolded alpha-synuclein in the dopaminergic neurons derived from fibroblasts of patients with Parkinson's disease.
Time frame: Baseline
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