Comparing Erector Spinae Plane (ESP) and Thoracic Paravertebral (TPV) Block Analgesic Effect After Elective VATS

Andrea Saporito50 enrolled

Overview

The aim of the study is to compare two different locoregional techniques in VATS.

There are clear clinical and logistic reasons for pursuing the best possible post-operative pain management avoiding the negative side effects of opioid treatment; in order to garantee an enhanced recovery after surgery. A short hospital stay is fundamental to reduce patient morbidity and costs. Regional anesthetic nerve blocks are an ideal option to achieve this goal. Paravertebral block serves as an ideal approach for thoracic and abdominal surgery through delivering segmental anesthesia of operative sites. Thoracic paravertebral block has superior analgesia as well as fewer complications than systemic opioids. It has been successfully applied in sternotomy, breast surgery, abdominoplasty, and laparoscopic cholecystectomy. ESP block is a recently described technique, with promising results in different scenarios. It probabily has a better risk profile than PVB, for its lower possibility of accidental pleural puncture and reabsorption of local anesthtetic than PVB one

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Surgery Thoracic

Interventions

ESP blockPROCEDURE

US guided ESP infiltration (saline solution vs Ropivacaine 0.375% according to randomization): unilateral injection of 0,4 ml kg -1 (ideal weight)2 under US guidance between the deep fascia of erector spinae muscle and the two transverse processes at the level of the 5th thoracic vertebrae. Duration approximately 10-15 minutes

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patients over 18 year of age undergoing elective VATS lung resection at ORBV Exclusion Criteria: * patients with inability to consent, contraindications to standard care, or factors that can cause bias in interpretation, absolute contraindications to the regional anesthesia techniques studied (patient's refusal, allergy to local anesthetics, infections in the site of injection). Pregnant women are not a target study-group so they are excluded for design simplification. Conversion to the open technique will be a post-randomization exclusion factor concerning the main outcomes

Locations (1)

Ente Ospedaliero Cantonale, Bellinzona

Bellinzona, Bellinzona, Switzerland

Outcomes

Primary Outcomes

cumulative dose of opioids at 24 and 48 h

by using a PCA we will see how many times the patient asked for analgesia

Time frame: 48 hours

Secondary Outcomes

Pain scores at 4h, 8h, 24h, 48h via numeric rating scale (NRS) at rest and during cough

we will test pain score in several moment by asking the NRS scale at rest and during cough

Time frame: 48 hours

Hypotension

we will compare the systolic pressure before anesthesia and after the block have been performed

Time frame: 48 hours

Cardio-pulmonary complications

we will check if any cardio-pulmonary complication is present after surgery during the hospital stay

Time frame: 48 hours

Procedure time and complications

we will observe the time necessary to perform the block and the complications after it

Time frame: 48 hours

Need for anti-nausea medication (dosage, doses and time points)

We will observe if the patient need any type of anti-nausea medication

Time frame: 48 hours

Episodes of vomiting

We will observe if any episode of vomiting is present

Time frame: 48 hours

Episodes of urinary retention

We will observe if any episode of urinary retention is present

Data from ClinicalTrials.gov

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