Evaluation of the Effectiveness of the Self-developed Pulmonary Lobar Ventilation Detector

Inclusion Criteria: * Patients with chronic obstructive pulmonary disease who meet the GOLD diagnostic criteria * FEV1 ≤ 45% pred and FEV1/FVC\<70% * TLC\>100% pred and RV\>175% pred * CAT≥18 * \>50% of emphysema destruction * Smoking prohibition\>6 months * Sign the informed consent form Exclusion Criteria: * PaCO2\>8.0 kPa, or PaO2\<6.0 kPa * 6-minute walking test\<160m * Obvious chronic bronchitis, bronchiectasis or other infectious lung diseases * Three hospitalizations due to pulmonary infection in the past 12 months before the baseline assessment * Previous lobectomy, LVRS or lung transplantation * LVEF\<45% and or RVSP\>50mmHg * Anticoagulant therapy that cannot be stopped before surgery * The patient has obvious immune deficiency * Participated in other lung drug studies within 30 days before this study * Pulmonary nodules requiring intervention * Any disease or condition that interferes with the completion of the initial or subsequent assessment