A Exploratory Trial of WTX221 in Refractory Gout Patients

Inclusion Criteria: * Fully understand the purpose and requirements of this trial, voluntarily participate in the clinical trial and sign the informed consent form, and be able to complete all trial processes as required by the protocol; * Subject is ≥ 18 years of age; * Patients with refractory gout: multiple tophi, more than 2 sites; * Subjects (males and females) must agree to be free of childbearing potential and willing to use effective contraception with their partner and have no plans to donate sperm or eggs during the trial and for at least 1 year after the infusion. Exclusion Criteria: * Patients with allergic diseases or specific allergic history, or possible allergic to the study drug and any of its components or related preparations; * Patients unable to communicate or cooperate with medical staff due to neurological, mental illness or language disorder, which affects patient compliance; * Having any past or present medical history that may affect the safety of the trial or the in vivo process of the drug, especially history of cardiovascular, liver, kidney, digestive tract, lung, spleen, nerve, blood, tumor, immune or metabolic disorders that are considered clinically significant by the investigator; * Participated in other drug or medical device clinical trials within 3 months before screening; * Patients who have received intravenous anti-infective treatment or active infection within 14 days before administration; * Patients with history of allogeneic organ, bone marrow transplantation or stem cell transplantation; * Patients with laboratory abnormalities that are clinically significant: * The investigator believes that it will prevent the subject from following and completing any other circumstances of the study protocol;