Turmeric Gel as Alternative Non-vital Pulpotomy Medicament in Primary Teeth

University of Health Sciences Lahore40 enrolled

Overview

The purpose of this randomized controlled clinical trial is to use Turmeric gel as non-vital Pulpotomy medicament compared to Formocresol in primary teeth by evaluating its antibacterial effect against Streptococcus mutans and Lactobacillus acidophilus. It is hypothesized that there is no difference in the antibacterial effect of Turmeric gel compared with Formocresol, when used as non-vital Pulpotomy medicaments.

It is a multi-arm parallel Randomized Controlled Trial in which forty patients aged between 4 to 8 years, each containing at-least one non-vital primary molar, will be selected and randomly divided into Group A (Formocresol) and Group B (Turmeric gel). Non-vital Pulpotomy will be performed by removing the coronal necrotic pulp. Sterile paper point will be dipped in the root canals and taken to the laboratory. Cotton pellets soaked in the respective medicaments will be placed over the root canal orifices and filled temporarily. Patients will be recalled after one week. Samples will be again taken, and tooth restored. Comparison between bacterial count at baseline and after one week of treatment will be made and expressed as Colony-Forming Units/ml (CFU/ml).

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Non-Vital Tooth

Interventions

Turmeric GelDRUG

Turmeric gel will be used as non-vital pulpotomy medicament compared with Formocresol (which is gold standard)

FormocresolDRUG

Formocresol will be used as non-vital pulpotomy medicament (which is gold standard)

Eligibility

Sex: ALLMin age: 4 YearsMax age: 8 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. Cooperation of patients and consent of parents. 2. Patients with ASA classification I and II (mild to moderate systemic disease). 3. Non-traumatic extensively carious hence restorable primary molars. 4. No history of antibiotic use for 2 weeks. 5. Presence of following clinical signs or symptoms suggestive of non-vital tooth such as tenderness on percussion, non-responsive to cold test, periapical/furcal radiolucency, localized gingival/mucosal soreness/ redness/ swelling, and/or slight mobility-grade I. Exclusion Criteria: 1. History of allergy to anesthetics and latex. 2. Radiographic evidence of pulpal floor opening into the furcation area. 3. More than half of the roots resorbed.

Locations (1)

de' Montmorency College of Dentistry

Lahore, Punjab Province, Pakistan

Outcomes

Primary Outcomes

Antibacterial effect

Bacterial count of S. mutans and L. acidophilus counted as Colony Forming Units/ml (CFU/ml)

Time frame: 1 week

Data from ClinicalTrials.gov

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