Continuous Infusion of Remidazolam for Colonoscopic Polypectomy in Elderly Patients

Tongji Hospital114 enrolled

Overview

To observe the sedative effect of continuous infusion of remidazolam in elderly patients undergoing colonoscopic polypectomy.

To observe the sedative effect of continuous infusion of remidazolam in elderly patients undergoing colonoscopic polypectomy, and to screen the optimal dose of remidazolam, in order to provide a more reasonable and safe sedative and analgesic drug regimen for elderly outpatients undergoing colonoscopic polypectomy.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Enrollment

114

Conditions

Colon Disease

Interventions

RemimazolamDRUG

Using two different doses of remidazolam for continuous pumping to maintain anesthetic effect

PropofolDRUG

propofol 2-3mg/kg/h

Eligibility

Sex: ALLMin age: 60 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age 60-80 years old; * ASA Level I - III; * Operation time: 15min\~1h; * BMI18.0-29.9； Exclusion Criteria: * Emergency surgery; * Patients with high risk of gastric satiety and reflux aspiration; * Allergies to benzodiazepines and opioids; * Those who have taken sedative, analgesic, or antidepressant drugs within 24 hours; * Abnormal liver and kidney function; * Previous drug use history; * Recently participated in other clinical studies; * Patients who cannot cooperate with communication.

Locations (1)

Tongji Hospital

Wuhan, Hubei, China

Outcomes

Primary Outcomes

Sedation success rate

Evaluating the success rate of sedation using the modified MOAA/S scoring table

Time frame: 1 day

Secondary Outcomes

Intraoperative time record

Anesthesia time; Operation time; Wake up time; PACU time

Time frame: Intraoperative

Drug usage

doses of propofol,remimazolam and other drugs used

Time frame: 1 day

The incidence of adverse reactions during surgery

includes: body movements, hypoxemia, hypotension, bradycardia; Intraoperative awareness

Time frame: 1 day

Incidence of postoperative adverse reactions

Postoperative nausea and vomiting, postoperative pain, hypotension, bradycardia, dizziness

Time frame: 24 hours after surgery

Data from ClinicalTrials.gov

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