Neurophysiological Evaluation of Residual Cognitive Functions in Patients With Severe Alterations of Consciousness

IRCCS Centro Neurolesi Bonino Pulejo20 enrolled

Overview

Identify potential markers of recovery through event-related potentials (ERPs) in the evolution of altered consciousness with potential ability to discriminate between different conditions of altered state of consciousness. Identify potential markers with prognostic value, in order to identify personalized and specific intensive rehabilitation paths based on the outcome indexes obtained.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Consciousness Disorder Cognitive Impairment

Interventions

Neurowave GroupDIAGNOSTIC_TEST

Neurosensory stimulation will consist in the administration of pairs of stimuli consisting of emotionally significant images and sounds in the personal life history (two rare stimuli) alternating with neutral images and sounds devoid of emotional significance (two "distracting" stimuli

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * Glasgow Coma Scale (GCS) \> 8; Level of Cognitive Scale (LCF) = 1-3; Signature of the consent from the family member and/or guardian. Exclusion Criteria: * Failure to sign the consent of the family member and/or legal guardian; Patients with cranial anatomical alterations that do not allow the correct assembly of the electrodes, caps, etc.; Patients with absence of neurophysiological responses in visual evoked potentials (VEP) and with absence of peripheral waves (I-II wave) to acoustic potentials (PEA).

Locations (1)

IRCCS Centro Neurolesi "Bonino-Pulejo"

Messina, Italy

Outcomes

Primary Outcomes

Event-related evoked potentials(ERPs)

Event-related evoked potentials(ERPs) are variations of the electric potential deriving from a visual, somesthetic or auditory stimulus.

Time frame: 24 months

Data from ClinicalTrials.gov

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