By including patients with acute myocardial infarction, mast cell markers were analyzed and the relationship between mast cells and patients with acute myocardial infarction was analyzed
Percutaneous coronary intervention (PCI) is the best way to improve the prognosis of patients with acute ST-segment elevation myocardial infarction (STEMI). However, ischemia reperfusion injury, inappropriate ventricular remodeling, and myocardial fibrosis may still be present in STEMI after PCI, which may be related to the inflammatory response in STEMI. Mast cells (MC), their degranulation products and induction of a series of inflammatory cytokines play an important role in the inflammatory response. The purpose of this study was to evaluate the relationship between mast cell markers (trypsin, chymotrypsin) levels and prognosis after direct PCI in STEMI patients. We prospectively and continuously included STEMI patients undergoing standard therapy after direct PCI. Clinical data and blood samples were collected and followed up for 1 year to analyze mast cell markers and myocardial infarction size. As well as differences in echocardiography, markers of two-dimensional speck tracking techniques, inflammatory factors and major adverse cardiovascular events, to explore the relationship between mast cells and their products and ventricular remodeling and ischemia-reperfusion injury in STEMI patients, and to provide new ideas for treatment and new basis for optimization of STEMI treatment strategies.
Study Type
OBSERVATIONAL
Enrollment
300
Serum samples were collected from patients within 24 hours, 1 month, 3 months and 12 months after myocardial infarction, and trypsin-like enzymes were determined by elisa
Myocardial infarct size
Myocardial infarct size was assessed by cardiac MRI
Time frame: 3 months after myocardial infarction
left ventricular systolic function
Transthoracic echocardiography to measure LVEF, left ventricular end-diastolic diameter, Em/Sm
Time frame: 24 hours, 1 month, 3 months, and 12 months after myocardial infarction
Left ventricular ultrasound strain
Two-dimensional speckle tracking imaging measures the movement in the long-axis direction as the overall longitudinal strain, the movement in the short-axis direction as the overall radial strain, reflecting the degree of wall systolic thickening, and the annular motion in the short-axis direction as the overall circumferential strain
Time frame: 24 hours, 1 month, 3 months, and 12 months after myocardial infarction
inflammatory marker such as TNF-α
Time frame: 24 hours, 1 month, 3 months, and 12 months after myocardial infarction
inflammatory markers e.g. IL1, IL6
Time frame: 24 hours, 1 month, 3 months, and 12 months after myocardial infarction
MC marker (chymotrypsin)
Time frame: 24 hours, 1 month, 3 months, and 12 months after myocardial infarction
major adverse cardiovascular events
MACE events (death, nonfatal myocardial infarction, unplanned revascularization, hospitalization for angina and readmission for heart failure)
Time frame: 12 months
Ming Cui, Doctor
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