This cross-sectional study aims to ascertain the mechanical properties of human carotid/femoral atherosclerotic plaque and abdominal aortic aneurysm tissue and correlate tissue mechanics with novel blood-based biomarkers of cardiovascular calcification.
The study is a non-randomised, controlled, cross-sectional study of diseased human carotid, femoral and abdominal aortic tissue.
Study Type
OBSERVATIONAL
Enrollment
300
No intervention.
University Hospital Limerick
Limerick, Limerick, Ireland
RECRUITINGCalcification feature classification
Identification of particular calcification features of plaque tissue and their influence on mechanical properties which may help clarify the success of stenting in certain patient cohorts compared to others and elucidate the procedural risk of endovascular treatments in plaque with certain calcification types.
Time frame: 10 years
Biomarker Analysis
Identification of novel biomarkers of vascular calcification could potentially be used as a predictive tool to highlight those at greatest risk of adverse peri-operative events, to allow for tailored medical treatment approaches and to stream-line patient care and improve patient outcomes.
Time frame: 10 years
Cardiovascular Health Critical Mass
To build a critical mass in cardiovascular health, an area of strategic importance for healthcare in Ireland.
Time frame: 10 years
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