This clinical trial aims to clarify the effect of hyaluronic acid on skin conditions.
In this study, investigators will evaluate the skin condition before and after the intervention. The groups to be compared are two different doses of hyaluronic and a placebo.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
36
Take 2 capsules per day at any time.
Take 2 capsules per day at any time.
Take 2 capsules per day at any time.
Ueno Asagao Clinic
Taito-ku, Tokyo, Japan
Change from baseline skin viscoelasticity
In skin viscoelasticity measurement using Cutometer MPA580®, skin displacement is measured by applying negative pressure to the skin through the opening of the probe and releasing the negative pressure. The higher the value, the greater the viscoelasticity. Measurement part:Measure the center of the left face, connecting the bottom of the earlobe and the edge of the lip. Accepted value:Measure the same place 5 times, and use the average of 3 measurements with the highest and lowest value data removed based on the R2 value. Analysis target value:R0, R2, R5, R7
Time frame: Week0, 2, 4, 8 and week 4 after the end of intake
Change from baseline skin moisture content
Skin moisture content is evaluated by using a Corneometer CM825®t
Time frame: Week0, 2, 4, 8 and week 4 after the end of intake
Change from baseline trans-epidermal water transpiration
Trans-epidermal water transpiration is evaluated by using Tewameter TM300®
Time frame: Week0, 2, 4, 8 and week 4 after the end of intake
Change from baseline VISIA image
Analyze the following items are measured and simply by putting face into VISIA Evolution. Measurement points:Photograph the left face Analysis target value:Blemishes, Wrinkles, Texture. Pores, Ultraviolet Blemishes, Brown Blemishes, Red Areas, Porphyrin.Higher numbers for these items indicate more advanced aging. Gloss is measured by VISIA-CR.
Time frame: week 0, 2, 4, 8 and week 4 after the end of intake
Change from baseline face visual evaluation
Face visual evaluation is measured by the dermatologist. Evaluation items:Cutaneous carpus, cutaneous groove, comprehensive evaluation Evaluation site:Evaluation centered on the left face, connecting the lower earlobe and the edge of the lip Evaluation method:Perform visual judgment using DermLite DL100 (J Hewitt Co., Ltd.) and microscope (KH-1300/HXG-2016Z/HIROX). There are 5 levels of evaluation, and judgment is made using the following criteria. -2 (Poor), -1 (Slightly Poor), 0 (Normal), 1 (Somewhat Good), 2 (Good) Time Frame: Week 0, 2, 4, 8 and week 4 after the end of intake
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Time frame: Week0, 2, 4, 8 and week 4 after the end of intake