Bone Intake Proteins and Muscle Mass Deficiency in Proximal Femur Fractures

Medical University of Warsaw40 enrolled

Overview

The aim of this clinical trial is to compare serum concentration of bone intake proteins \[ sex hormone-binding globulin (SHBG), cross linked C-telopeptide of type I collagen (CTX-I)\] and muscle atrophy marker \[creatine kinase (CK-MB)\] between patients after the fracture of proximal femur and their age corresponding counterpart without the fracture. The main question it aims to answer is: • Is the higher concentration of bone intake proteins and muscle atrophy marker a predictive factor of proximal femur fracture? The part of participants (Group 1) will be hospitalized at the Department of Orthopaedics and Rehabilitation and will undergo a surgical treatment (open reduction of the fracture). The rest (Group 2) will be admitted to the Department of Internal Medicine. Participants of both Groups will have the blood sample test taken, to evaluate and compare the serum concentration of SHBG, CTX-I and CK-MB proteins.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Femoral Neck Fractures Pertrochanteric Fracture Bone Resorption Bone Loss Muscle Loss Muscle Damage

Interventions

Surgical treatment of proximal femur fracture and blood sample testPROCEDURE

Open reduction of femoral neck or pertrochanteric fracture with hemi/total hip arthroplasty or gamma nail. Analysis of serum concentration of: SHBG, CTX - I, CK-MB

Blood sample testPROCEDURE

Analysis of serum concentration of: SHBG, CTX - I, CK-MB

Eligibility

Sex: ALLMin age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Age over 65 * Proximal femur fracture (Group 1) Exclusion Criteria: * neoplasmatic history in the anamnesis, * prevalent fracture * mental illness * immune disease affecting protein balance

Outcomes

Primary Outcomes

Serum concentration of SHBG and comparison between intervention groups

Time frame: (Group 1) At the day of the admission to the Department of Orthopaedics and Rehabilitation prior the surgical treatment or (Group 2) at the day of the admission to the Department of Internal Medicine

Serum concentration of CTX-I and comparison between intervention groups

Serum concentration of CK-MB and comparison between intervention groups