Peri-Implant Soft Tissue Integration in Humans: Influence of Material

Inclusion Criteria: * Participants have to voluntarily sign the informed consent form before any study related action * Patients aged 18 or over * Patients with one or more missing teeth in the maxillary or mandible area, seeking implant therapy * Men/women * Patients in good systemic health (ASA I/ II) and no contraindication for oral surgical interventions * Patients requiring a replacement of missing teeth; the tooth at the implant site(s) must have been extracted or lost at least 12 weeks before the date of implantation * At least 3 mm of fibrous mucosa in the bucco-lingual dimension * Full mouth plaque score (FMPI) lower than or equal to 25% * At least a diameter of 4 mm for the implant (regular diameter) Exclusion Criteria: * Autoimmune disease requiring medical treatment * Medical conditions requiring prolonged use of steroids * Use of Bisphosphonates intravenously or more than 3 years of oral use * Infection (local or systemic) - patients with gingivitis or active local infection will undergo a medical treatment prior to the entrance to the study, and each individual will be evaluated for suitability; in case of a systemic infection, the evaluation will be based on medical anamneses, and if necessary, a patient will be referred to relevant medical tests * Current pregnancy or breastfeeding women * Alcoholism or chronical drug abuse * Immunocompromised patients * Uncontrolled diabetes * Smokers * Prisoners * Implant's diameter under 4 mm (narrow implant) * Conditions or circumstances, in the opinion of the investigator, which would prevent completion of the study or interference with analysis of study results, such as history of non-compliance, or unreliability