Evaluation of the Safety and Effectiveness of Percutaneous and Transbronchial Argon-helium Cryoablation

Inclusion Criteria: * Primary or metastatic lung cancer with definite pathological diagnosis * Not suitable for thoracotomy due to serious or serious lung or systemic diseases * Peripheral lung cancer involves pleura and chest wall, and cannot be completely removed after surgery * There are indications for surgical resection, but the patient refuses to operate * Single tumor, maximum diameter ≤ 5cm * Or the number of tumors ≤ 3 and the maximum diameter ≤ 3cm * ECOG-PS score ≤ 2 * The expected survival period is more than three months * Those who have not participated in other clinical verifications within 3 months * Subjects voluntarily signed the informed consent form Exclusion Criteria: * Serious cardio-cerebral disease or other mental diseases * Severe pulmonary fibrosis, especially drug-induced pulmonary fibrosis * Patients with previous severe pulmonary dysfunction, pulmonary ventilation disorder and multiple pulmonary bullae * Have a history of immunodeficiency, including HIV test (enzyme-linked immunosorbent assay and Western blotting) positive * Chemotherapy, radiotherapy, interventional therapy, ablation and surgical treatment within 30 days before surgical treatment * There is a tendency to severe bleeding, and the platelet is less than 50 × 109/L and severe disorder of coagulation function * Coagulation index (PT, TT, APTT)\>2.5 times of the upper normal limit * Malignant pleural effusion on the same side of the ablation focus was not well controlled * Poor general condition, multiple organ failure, cachexia, severe anemia and nutritional metabolism disorder * Those who have extensive extrapulmonary metastasis and are not suitable for ablation treatment * Those who often use sedatives, sleeping pills, tranquilizers or other addictive drugs * Pregnant or lactating women * Those who can not judge the curative effect * Other conditions determined by the researcher to be unsuitable for the group, such as inability to tolerate cryoablation, difficulty in follow-up, and other serious diseases