A Study to Evaluate the Safety and Efficacy of 2ccPA in Patients With Symptomatic Knee Osteoarthritis

Inclusion Criteria: 1. Signed written informed consent from any patient capable of giving consent. 2. Male or female patients, 40 to 80 years of age. 3. Documented clinical diagnosis of symptomatic OA affecting at least one knee of a minimum of 6 months prior to screening. 4. The study knee has OA of Grade 2 to 3 severity based on the Kellgren Lawrence grading scale. 5. A score \> 6 and \< 16 out of 20 on the WOMAC pain subscale for the study knee. 6. Pain in the study knee for most of the 30 days (i.e., more than half of the days) prior to randomization. 7. Women of childbearing potential must agree to practice a medically acceptable contraceptive regimen from screening visit until at least 1 month after the study treatment and must have a negative pregnancy test no earlier than 72 hours prior to study treatment. Male subjects must agree to practice a medically acceptable contraceptive regimen (i.e., sterilization surgery, barrier method, abstention) from screening visit until at least 1 month after the study treatment. Exclusion Criteria: 1. Patients with known or suspected hypersensitivity to 2ccPA or any of its excipients. 2. Use of intra-articular corticosteroids, hyaluronic acid, or other IA injection in the study knee within 3 months prior to study entry (randomization). 3. Use of chondroitin and/or glucosamine within 4 weeks prior to study entry (randomization). 4. Administered or requiring systemic or topical treatment of the study knee joint including immunosuppressive agents, anti-inflammatory drugs, steroids, or opioids for knee OA within 1 week prior to randomization. Acetaminophen (oral daily dose ≤ 3000 mg or topical use at any dose) can be taken up to 24 hours prior to randomization. For long-acting steroids (i.e., dexamethasone, betamethasone), subjects who received systemic treatment within 2 weeks before randomization will be excluded. 5. History of post-traumatic knee arthritis, or evidence of intra-articular bleeding of the study knee. 6. History of reiter's syndrome, gouty arthritis, systemic lupus erythematosus (SLE), sicca syndrome, rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, lymphoma, arthritis associated with inflammatory bowel disease, sarcoidosis, amyloidosis or any other immune disease that based on investigators' discretion. 7. Periarticular inflammation from any cause, including referred pain, bursitis, tendonitis, soft tissue tenderness or acute pain from injury. 8. Subjects with clinical signs and symptoms of active knee infection or being treated for knee infection at screening. 9. Arthroscopic or open surgery on the study knee within 6 months prior to study entry (randomization). 10. Prior knee replacement on the study knee or planned knee replacement during the study period. 11. Subjects with meniscus tears that require repairment surgery or known anterior cruciate ligament rupture. 12. Subjects with known severe synovitis, synovium necrosis in the study knee joint. 13. Subjects with known malignancy. 14. Use of any chemotherapeutic or systemic immunosuppressant agents for inflammatory diseases within 6 months prior to study entry (randomization). 15. Current use of anticoagulants, including warfarin, heparin, low molecular weight heparin, dabigatran, or factor Xa inhibitors (rivaroxaban, apixaban, edoxaban, and betrixaban). Subject requiring routine use of low-dose aspirin for preventing thrombosis (≤ 100 mg/day) will not be excluded. 16. Abnormalities of laboratory parameters as described below will qualify for exclusion: * hemoglobin \< 8 g/dL * total white blood cell count \< lower limit of normal (LLN) * serum bilirubin/ alanine aminotransferase (ALT)/ aspartate aminotransferase AST \> 2.5 times upper limit of normal (ULN) * serum creatinine \> 2 times ULN 17. Pregnancy or lactation. 18. History of drug or alcohol dependence in the past 3 years. 19. Having known infection with HIV-1, active hepatitis B, or active hepatitis C. Patients who are inactive carriers of HBV or HCV can be enrolled if the subjects have stable baseline condition during the screening period. 20. Use of any investigational drug or participation in any drug study within 4 weeks prior to study entry (randomization). 21. Subjects unwilling or unable to comply with study procedures. 22. Any clinical condition, including the presence of laboratory abnormalities, which places the subject at unacceptable risk to participate in the study or confounds the ability to interpret data from the study as judged by the investigator.