Fractionated Busulfan Conditioning Regimen for Allo-HSCT in Non-remission Myeloid Malignancies

Inclusion Criteria: 1. Age ≥ 18 years old and ≤ 65 years old when signing the Informed Consent Form (ICF); 2. KPS score \> 60 or ECOG score 0-2; 3. The expected survival period \> 3 months; 4. Those who did not achieve complete remission after 2 or more chemotherapy regimens. The proportion of blasts on bone marrow smears before transplantation was ≥5%. 5. Those who have no central nervous system involvement or serious functional damage to important organs of the body; 6. Fully understand and be informed of this study and sign the ICF; willing to follow and have the ability to complete all test procedures; Exclusion Criteria: 1. Serious basic diseases of important organs: such as myocardial infarction, chronic cardiac insufficiency, decompensated hepatic insufficiency, renal function, gastrointestinal insufficiency, etc.; 2. Uncontrolled active infection (including bacterial, fungal, or viral infection), and drug treatment is ineffective; 3. Participating in other clinical studies, or planning to start treatment in this study and less than 4 weeks before the end of treatment in the previous clinical study; 4. Combined with other malignant tumors and require treatment; 5. Pregnant or lactating females; 6. Patients with known history of human immunodeficiency virus (HIV) virus infection and/or acquired immunodeficiency syndrome; 7. Patients with active chronic hepatitis B or active hepatitis C; 8. History of prolonged QT syndrome; 9. Patients considered by other researchers to be unsuitable for this study